Results 111 to 120 of about 343,872 (339)

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non‐heading Chinese Cabbage

open access: yesAdvanced Science, EarlyView.
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang   +10 more
wiley   +1 more source

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

open access: yesAdvanced Science, EarlyView.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen   +8 more
wiley   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang   +9 more
wiley   +1 more source

Trajectories of unsecured debt and health at midlife

open access: yesSSM: Population Health, 2021
Background: Unsecured debt — debt not tied to an asset — is a financial stressor that undermines health, but prior research has not investigated relationships between group-based trajectories of unsecured debt and pain and disability at midlife. Methods:
Adrianne Frech   +2 more
doaj  

Tactile Augmentation of Material Classification via Imperceptible On‐Skin Triboelectricity Collection

open access: yesAdvanced Science, EarlyView.
Human skin inherently forms a body‐coupled triboelectric circuit that enables the generation of triboelectric charges through contact between the skin surface and various materials. Integrated with an on‐finger, substrate‐free microfiber electrode, the material‐specific and personalized triboelectric signals can be imperceptibly collected for machine ...
Junting Huang   +7 more
wiley   +1 more source

OLD AGE AND MONEY: THE GENERAL NUMISMATICS OF KENYA

open access: yesSuomen Antropologi, 2016
This research report examines the relationship between promissory acts and promissory notes in Kenyan history and its popular imagination. In Jomo Kenyatta’s classic ethnography of the Kikuyu, Facing Mount Kenya, he decries the corrosive power of money ...
Robert Blunt
doaj  

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

open access: yesAdvanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu   +6 more
wiley   +1 more source

Development of training-related health care software by a team of clinical educators: their experience, from conception to piloting

open access: yesAdvances in Medical Education and Practice, 2016
Derfel ap Dafydd,1 Ruth Williamson,2 Philip Blunt,3 Dominic M Blunt4 1Department of Radiology, Royal Marsden NHS Foundation Trust, London, 2Imaging Department, Royal Bornemouth Hospital, Bornemouth, 3Savernake IT Ltd, Marlborough, 4Imaging Department ...
ap Dafydd D   +3 more
doaj  

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