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Proceedings of the 2014 ACM/SIGDA international symposium on Field-programmable gate arrays, 2014
With the wide application of FPGAs in adaptive computing systems, there is an increasing need to support design automation for PR FPGAs. However, there is a missing link between CAD tools for PR FPGA and existing widely used CAD tools, such as VPR. Hence, in this work we propose a modular placer for FPGAs because each PR region needs to be identified ...
Fubing Mao +3 more
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With the wide application of FPGAs in adaptive computing systems, there is an increasing need to support design automation for PR FPGAs. However, there is a missing link between CAD tools for PR FPGA and existing widely used CAD tools, such as VPR. Hence, in this work we propose a modular placer for FPGAs because each PR region needs to be identified ...
Fubing Mao +3 more
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BMP and BMP Inhibitors in Bone
Annals of the New York Academy of Sciences, 2006Abstract: Bone morphogenetic proteins (BMPs) are signaling molecules that act locally on target cells to affect cell survival, proliferation, and differentiation. While first identified as bone‐inducing agents, BMPs are now known to affect the formation and function of many organ systems. Here we focus only on the roles of BMPs in the skeleton.
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Molecular recognition of BMP-2 and BMP receptor IA
Nature Structural & Molecular Biology, 2004Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta superfamily regulate the development, maintenance and regeneration of tissues and organs. Binding epitopes for these extracellular signaling proteins have been defined, but hot spots specifying binding affinity and specificity have so far not been identified.
Sascha, Keller +4 more
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Heparin inhibits BMP‐2 osteogenic bioactivity by binding to both BMP‐2 and BMP receptor
Journal of Cellular Physiology, 2008AbstractHeparin demonstrates several kinds of biological activities by binding to various extracellular molecules and plays pivotal roles in bone metabolism. However, the role of heparin in the biological activity of bone morphogenetic protein (BMP) remains unclear.
Shin, Kanzaki +6 more
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BMP and BMP Regulation: Structure and Function
2017Due to their vast roles in human development, differentiation, homeostasis, and disease, bone morphogenetic proteins (BMP) have evolved along with numerous potentiating and inhibitory mechanisms to fine-tune signaling outcomes. As such, this chapter focuses on some of the best-studied and utilized extracellular mechanisms of BMP signal regulation.
Kristof Nolan, Thomas B. Thompson
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BMP Signaling and Skeletogenesis
Annals of the New York Academy of Sciences, 2006Abstract: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)‐β superfamily of signal molecules that mediate many diverse biological processes ranging from early embryonic tissue patterning to postnatal tissue homeostasis. BMPs trigger cell responses mainly through the canonical signaling pathway where intracellular
Xuelin, Li, Xu, Cao
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Injury, 2005
Bone morphogenetic proteins (BMPs) are polypeptides discovered by Marshall Urist in 1965 and later defined by his co-workers as multifunctional cytokines involved in osteoinduction. They are members of the transforming growth factor-beta superfamily with the exception of the BMP-1.
De Biase, Pietro, Capanna, Rodolfo
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Bone morphogenetic proteins (BMPs) are polypeptides discovered by Marshall Urist in 1965 and later defined by his co-workers as multifunctional cytokines involved in osteoinduction. They are members of the transforming growth factor-beta superfamily with the exception of the BMP-1.
De Biase, Pietro, Capanna, Rodolfo
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BRAM1, a BMP receptor‐associated molecule involved in BMP signalling
Genes to Cells, 1998BackgroundTGF‐β superfamily members elicit signals through the stimulation of serine/threonine‐kinase receptors. Recently, molecules associated with several TGF‐β family receptors have been cloned. One such molecule, the immunophilin FKBP12, has been reported to interact with TGF‐β family type I receptors.
K, Kurozumi +5 more
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Human osteophytes produce BMP-3 & BMP-7
Bone (New York, N.Y.), 1999Osteophytes are newly formed osseous and cartilaginous tissue outgrowths forming mostly at the margin of osteoarthrotic joints. They are extremely variable and irregular in size and shape but it seems that they develope and growth by the same processes of intramembranous and endochondral ossification as bones in embryonal development.
Zoričić Cvek, Sanja +3 more
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Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair
Bone, 2010Bone morphogenetic proteins (BMPs) are potent bone inducers used clinically to enhance fracture repair. BMPs have been shown to be produced in the fracture callus; however, the comparative expression of BMPs and BMP signaling components has only been partially examined at the cellular level.
Yan Yiu, Yu +5 more
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