Results 171 to 180 of about 52,292 (275)

Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome

Immunology, Volume 177, Issue 3, Page 596-612, March 2026.
Decreased fetal brain macrophages were previously reported in Ts1Cje mice, a model of Down syndrome (DS). We confirmed the reduction in primitive macrophages, brain macrophage precursors, using Ts1Cje‐derived mouse embryonic stem cells (Ts1Cje‐mESCs) and human induced pluripotent stem cells with trisomy 21 (Tri21‐hiPSCs), with in vivo validation ...
Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata   +9 more
wiley   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Chrdl1-mediated BMP4 inhibition disrupts the balance between retinal neurons and Müller Glia

Cell Death Discovery
Chordin-like 1 (CHRDL1) is a secreted protein that serves as an endogenous antagonist of bone morphogenetic proteins (BMPs). In the developing retina, Bmp4 has been demonstrated to be essential for sustaining the proliferation of progenitor cells and ...
Dongmei Liu, Zeyuan Pu, Baige Li, Gao Tan, Ting Xie, Yin Shen   +5 more
doaj   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia

Stem Cells International, 2016
Spermatogenesis is sustained by the proliferation and differentiation of spermatogonial stem cells (SSCs). However, the molecules controlling these processes remain largely unknown.
Yongguang Yang, Yanmin Feng, Xue Feng, Shangying Liao, Xiuxia Wang, Haiyun Gan, Lixian Wang, Xiwen Lin, Chunsheng Han   +8 more
doaj   +1 more source

USAG‐1 and Regenerative Dentistry, Therapeutic Implications and Future Directions: Review of the Literature

Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.
ABSTRACT Objectives Uterine Sensitization‐Associated Gene 1 (USAG‐1) is a bone morphogenetic protein (BMP) antagonist vital for tooth regeneration that is expressed in kidney, gingiva, and dental tissues. Material and methods We analyzed recent studies focusing on USAG‐1 and its involvement in BMP and Wnt signaling pathways related to dental tissue ...
Zahra Moradi, Mohammadreza Karimi, Shirin Kolahdouz, Narges Arya, Vahid Akheshteh, Fatemeh Ayanzadeh, Yasmina Aalizadeh, Hanieh Moravvej, Marzie Keshavarzi, Amar Basri   +9 more
wiley   +1 more source

A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System

Aging Cell, Volume 25, Issue 2, February 2026.
Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global alterations related to immune function and identifies potential pathways and cell populations that can be targeted for therapeutic intervention.
Ryan R. White, Kun Xiong, Matthew Wakai, Allison Surian, Christina Adler, Nicole Negron, Min Ni, Tea Shavlakadze, Yu Bai, David J. Glass   +9 more
wiley   +1 more source

Comparison of Cell Viability and Embryoid Body Size of Two Embryonic Stem Cell Lines After Different Exposure Times to Bone Morphogenetic Protein 4

Iranian Journal of Medical Sciences, 2015
Background: Activation of bone morphogenetic protein 4 (BMP4) signaling pathway in embryonic stem (ES) cells plays an important role in controlling cell proliferation, differentiation, and apoptosis.
Nehleh Zarei Fard, Tahereh Talaei-Khozani, Soghra Bahmanpour, Tahereh Esmaeilpour   +3 more
doaj  

The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type

Aging Cell, Volume 25, Issue 2, February 2026.
Using multiple cell types and autologous immune cells, the authors present the first comprehensive evaluation of the immunogenicity of human senescent cells. Their findings demonstrate that, despite exhibiting a unique immunopeptidome, senescent fibroblasts are not recognized by immune cells.
Marie‐Lyn Goyer, Anthony Sonn, Basma Benabdallah, Oanh Le, Joshua Dulong, Joana Oschwald, Isabelle Sirois, Anca Apavaloaei, Leslie Hesnard, Jean V. Guimond, Elie Haddad, Christian Beauséjour   +11 more
wiley   +1 more source