Results 211 to 220 of about 46,344 (243)
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Augmented BMP4 signal impairs tongue myogenesis
Journal of Molecular Histology, 2021Tongue muscles are derived from mesodermal cells, while signals driven by cranial neural crest cells (CNCCs) regulate tongue myogenesis via tissue-tissue interaction. Based on such mechanisms of interaction, congenital tongue defects occur in CNC-related syndromes in humans.
Jian Zhang +4 more
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Comparative genomics on BMP4 orthologs
International Journal of Oncology, 2005Bone morphogenetic proteins (BMPs) are implicated in cell-fate determination of embryonic stem (ES) cells and cancer cells. GREM1 (CKTSF1B1 or DAND2) and CER1 (Cerberus 1 or DAND4) are cysteine knot superfamily proteins, functioning as secreted-type BMP antagonists. BMP4 is preferentially expressed in diffuse-type gastric cancer cells. Here, vertebrate
Yuriko, Katoh, Masaru, Katoh
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The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Bone morphogenetic proteins (BMPs) are made as inactive precursor proteins that dimerize and are cleaved to generate a bioactive ligand along with prodomain fragments that lack signaling activity. BMP ligands signal as either homodimers, or as heterodimers that display significantly higher activity in vivo.
Nathan Donley, Jan L Christian
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Bmp2 and Bmp4 accelerate alveolar bone development
Connective Tissue Research, 2014Alveolar bone remodeling is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking.
Mingming, Ou +3 more
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Endothelial BMP4 Regulates Leukocyte Diapedesis and Promotes Inflammation
Inflammation, 2017Leukocyte recruitment is a fundamental event in the response of the innate immune system to injury. This process is promoted in part by the opening of endothelial cell adherens junctions that allows leukocyte extravasation through gaps between adjacent endothelial cells.
Helbing, Thomas +12 more
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Mechanisms of BMP4 Regulation of Metastasis
2022Submitted in total fulfilment for the degree of Doctor of Philosophy to the Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Victoria.
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Organized Tooth-specific Cellular Differentiation Stimulated by BMP4
Journal of Dental Research, 2005Mammalian teeth develop on the oral surface of the first pharyngeal arch by a series of reciprocal interactions between epithelial and mesenchymal cells. The embryonic first pharyngeal arch oral epithelium is able to induce tooth formation when combined with mesenchymal cells from the second pharyngeal arch, a region devoid of tooth development ...
Ohazama, A, Tucker, A, Sharpe, P
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Controlling Tumor Invasion: Bevacizumab and BMP4 for Glioblastoma
Future Oncology, 2013Bevacizumab has been reported to result in increased tumor invasion when used to treat malignant glioma. We hypothesized that BMP4 would prevent diffuse tumor infiltration induced by bevacizumab for malignant glioma in a xenograft model.Human glioblastoma (GBM) tumor cells were implanted in the striatum of immunocompromised mice.
Maryam, Rahman +5 more
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BMP4 signaling mediates Zeb family in developing mouse tooth
Histochemistry and Cell Biology, 2012Tooth morphogenesis is regulated by sequential and reciprocal interaction between oral epithelium and neural-crest-derived ectomesenchyme. The interaction is controlled by various signal molecules such as bone morphogenetic protein (BMP), Hedgehog, fibroblast growth factor (FGF), and Wnt.
Nakagawa, E +6 more
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