Results 211 to 220 of about 32,745 (240)

Comparative genomics on BMP4 orthologs

International Journal of Oncology, 2005
Bone morphogenetic proteins (BMPs) are implicated in cell-fate determination of embryonic stem (ES) cells and cancer cells. GREM1 (CKTSF1B1 or DAND2) and CER1 (Cerberus 1 or DAND4) are cysteine knot superfamily proteins, functioning as secreted-type BMP antagonists. BMP4 is preferentially expressed in diffuse-type gastric cancer cells. Here, vertebrate
Yuriko, Katoh, Masaru, Katoh
openaire   +2 more sources

BMP4-Induced Suppression of Breast Cancer Metastasis Is Associated With Inhibition of Cholesterol Biosynthesis

International Journal of Molecular Sciences
We reported previously that in preclinical models, BMP4 is a potent inhibitor of breast cancer metastasis and that high BMP4 protein levels predict favourable patient outcomes.
Andrew D Redfern, Terry C C Lim Kam Sian, Roger J. Daly   +2 more
exaly   +3 more sources

Mechanisms of BMP4 Regulation of Metastasis

2022
Submitted in total fulfilment for the degree of Doctor of Philosophy to the Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Victoria.
openaire   +1 more source

Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis

Journal of Cellular Biochemistry, 2004
AbstractBone morphogenetic protein 4 (BMP4) and growth/differentiation factor 5 (GDF5) are closely related protein family members and regulate early cartilage patterning and differentiation. In this study, we compared the functional outcome of their actions systematically at various stages of chondrogenesis in mouse embryonic limb bud mesenchyme grown ...
Yuji, Hatakeyama, Rocky S, Tuan, Lillian, Shum   +2 more
openaire   +2 more sources

BMP4 Is Dispensable for Skeletogenesis and Fracture-Healing in the Limb

Journal of Bone and Joint Surgery, 2008
Bone morphogenetic proteins (BMPs) are potent bone-forming agents that show clinical efficacy when used in patients to augment fracture-healing. Molecular profiling of fracture tissues has confirmed that BMPs 2, 3, 4, 5, 6, and 7 are expressed during the healing process, and it has identified a specific temporal pattern of expression for each BMP. Mice
Kunikazu, Tsuji, Karen, Cox, Amitabha, Bandyopadhyay, Brian D, Harfe, Clifford J, Tabin, Vicki, Rosen   +5 more
openaire   +2 more sources

Bmp2 and Bmp4 accelerate alveolar bone development

Connective Tissue Research, 2014
Alveolar bone remodeling is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking.
Mingming, Ou, Yibing, Zhao, Fangming, Zhang, Xiaofeng, Huang   +3 more
openaire   +2 more sources

Controlling Tumor Invasion: Bevacizumab and BMP4 for Glioblastoma

Future Oncology, 2013
Bevacizumab has been reported to result in increased tumor invasion when used to treat malignant glioma. We hypothesized that BMP4 would prevent diffuse tumor infiltration induced by bevacizumab for malignant glioma in a xenograft model.Human glioblastoma (GBM) tumor cells were implanted in the striatum of immunocompromised mice.
Maryam, Rahman, Hassan, Azari, Loic, Deleyrolle, Sebastien, Millette, Huadong, Zeng, Brent A, Reynolds   +5 more
openaire   +2 more sources

A BMP4-angiomiR connection in angiogenesis

Thrombosis and Haemostasis, 2017
David, Sprott, Triantafyllos, Chavakis
openaire   +2 more sources

BMP4

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells

Frontiers in Immunology, 2021
Junji Xu
exaly