Results 241 to 250 of about 52,292 (275)

Augmented BMP4 signal impairs tongue myogenesis

Journal of Molecular Histology, 2021
Tongue muscles are derived from mesodermal cells, while signals driven by cranial neural crest cells (CNCCs) regulate tongue myogenesis via tissue-tissue interaction. Based on such mechanisms of interaction, congenital tongue defects occur in CNC-related syndromes in humans.
Jian Zhang, Chensheng Lin, Yingnan Song, Yanding Zhang, Jiang Chen   +4 more
openaire   +2 more sources

RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway

Journal of dentistry research, 2022
RUNX2 is a master osteogenic transcription factor, and mutations in RUNX2 cause the inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that RUNX2 is not only a downstream target of the bone morphogenetic protein (BMP ...
D. Liu, C.Y. Zhang, Y. Liu, J. Li, Y. Wang, S. Zheng   +5 more
semanticscholar   +1 more source

Comparative genomics on BMP4 orthologs

International Journal of Oncology, 2005
Bone morphogenetic proteins (BMPs) are implicated in cell-fate determination of embryonic stem (ES) cells and cancer cells. GREM1 (CKTSF1B1 or DAND2) and CER1 (Cerberus 1 or DAND4) are cysteine knot superfamily proteins, functioning as secreted-type BMP antagonists. BMP4 is preferentially expressed in diffuse-type gastric cancer cells. Here, vertebrate
Yuriko, Katoh, Masaru, Katoh
openaire   +2 more sources

Bmp2 and Bmp4 accelerate alveolar bone development

Connective Tissue Research, 2014
Alveolar bone remodeling is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking.
Mingming, Ou, Yibing, Zhao, Fangming, Zhang, Xiaofeng, Huang   +3 more
openaire   +2 more sources

Association of BMP4 rs17563 Polymorphism with Nonsyndromic Cleft Lip with or without Cleft Palate Risk: Literature Review and Comprehensive Meta-Analysis

Fetal and Pediatric Pathology, 2020
Background Although published individual studies have reported associations between BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCLP) risk, the results are conflicting.
R. Bahrami, S. Dastgheib, Seyed Mohammadreza Niktabar, A. Amooee, M. Lookzadeh, S. Mirjalili, M. Noorishadkam, Z. Bahrololoomi, H. Neamatzadeh   +8 more
semanticscholar   +1 more source

Role of the arecoline/YAP1/BMP4 pathway in promoting endothelial-mesenchymal transition in oral submucous fibrosis.

Journal of Oral Pathology & Medicine, 2020
BACKGROUND Oral submucous fibrosis (OSF) is a potentially malignant lesion characterized by epithelial-mesenchymal transition (EMT). Bone morphogenetic protein 4 (BMP4) promotes EMT in fibrotic diseases, but the underlying mechanisms and its potential ...
M. Yao, Jiang Li, ShanShan Yuan, Xilei Zhu, Zi-long Hu, Qiulan Li, R. Cao, Wenjin Wang, C. Fang   +8 more
semanticscholar   +1 more source

Endothelial BMP4 Regulates Leukocyte Diapedesis and Promotes Inflammation

Inflammation, 2017
Leukocyte recruitment is a fundamental event in the response of the innate immune system to injury. This process is promoted in part by the opening of endothelial cell adherens junctions that allows leukocyte extravasation through gaps between adjacent endothelial cells.
Helbing, Thomas, Arnold, Linus, Wiltgen, Gwendoline, Hirschbihl, Eva, Gabelmann, Valentin, Hornstein, Alexandra, Esser, Jennifer, Diehl, Philipp, Grundmann, Sebastian, Busch, Hans-Jörg, Fink, Katrin, Bode, Christoph, Moser, Martin   +12 more
openaire   +3 more sources

Mechanisms of BMP4 Regulation of Metastasis

2022
Submitted in total fulfilment for the degree of Doctor of Philosophy to the Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Victoria.
openaire   +1 more source

Organized Tooth-specific Cellular Differentiation Stimulated by BMP4

Journal of Dental Research, 2005
Mammalian teeth develop on the oral surface of the first pharyngeal arch by a series of reciprocal interactions between epithelial and mesenchymal cells. The embryonic first pharyngeal arch oral epithelium is able to induce tooth formation when combined with mesenchymal cells from the second pharyngeal arch, a region devoid of tooth development ...
Ohazama, A, Tucker, A, Sharpe, P
openaire   +3 more sources

Controlling Tumor Invasion: Bevacizumab and BMP4 for Glioblastoma

Future Oncology, 2013
Bevacizumab has been reported to result in increased tumor invasion when used to treat malignant glioma. We hypothesized that BMP4 would prevent diffuse tumor infiltration induced by bevacizumab for malignant glioma in a xenograft model.Human glioblastoma (GBM) tumor cells were implanted in the striatum of immunocompromised mice.
Maryam, Rahman, Hassan, Azari, Loic, Deleyrolle, Sebastien, Millette, Huadong, Zeng, Brent A, Reynolds   +5 more
openaire   +2 more sources