Results 261 to 270 of about 905,740 (294)
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Modulation of activin and BMP signaling
Molecular and Cellular Endocrinology, 2004Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related types I and II receptors. Here, we summarize recent advances in understanding the mode of action of activins and BMPs, focusing on our elucidation of the crystal structure of BMP-7 in complex with the extracellular ...
Craig A, Harrison +5 more
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Modulation of BMP signalling by integrins
Biochemical Society Transactions, 2016The bone morphogenetic protein (BMP) pathway is a major conserved signalling pathway with diverse roles in development and homeostasis. Given that cells exist in three-dimensional environments, one important area is to understand how the BMP pathway operates within such complex cellular environments.
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BRAM1, a BMP receptor‐associated molecule involved in BMP signalling
Genes to Cells, 1998BackgroundTGF‐β superfamily members elicit signals through the stimulation of serine/threonine‐kinase receptors. Recently, molecules associated with several TGF‐β family receptors have been cloned. One such molecule, the immunophilin FKBP12, has been reported to interact with TGF‐β family type I receptors.
K, Kurozumi +5 more
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BMP signalling in early Xenopus development
BioEssays, 1999Bone morphogenetic proteins (BMPs) are typically members of the transforming growth factor beta (TGF-beta) family with diverse roles in embryonic development. At least five genes with homology to BMPs are expressed during Xenopus development, along with their receptors and intracellular signalling pathways. The evidence suggests that BMPs have roles to
L, Dale, C M, Jones
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BMP Signaling in Skeletogenesis
2010Bone is a dynamic tissue that provides skeletal support to the body and is essential in the maintenance of hematopoiesis and calcium homeostasis. Bone development and remodeling are tightly regulated by local paracrine factors and systemic hormones.
Kristine D. Estrada, Karen M. Lyons
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Bmp signaling in molar cusp formation
Gene Expression Patterns, 2019Tooth cusp is a crucial structure, since the shape of the molar tooth is determined by number, shape, and size of the cusp. Bone morphogenetic protein (Bmp) signaling is known to play a critical role in tooth development, including in initiation. However, it remains unclear whether Bmp signaling is also involved in cusp formation.
Fumiya, Meguro +10 more
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BMP signalling specifies the pyloric sphincter
Nature, 1999Sphincters are muscular valves that form at the boundaries between organs of the gut; for example, the pyloric sphincter forms at the junction of the small intestine and stomach. We show here that signalling by bone morphogenetic protein (BMP) from the avian small intestine induces the cells of the adjacent gizzard (the equivalent of the stomach in the
D M, Smith, C J, Tabin
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Making sense of BMP signaling complexity
Cell Systems, 2022Cellular signaling systems are immensely complex. Dedicated experimental and theoretical approaches are therefore required to decipher how they function. In this issue of Cell Systems, two studies systematically interrogate the Bone Morphogenetic Protein (BMP) pathway, uncovering mechanisms and consequences of distinct responses to combinations of BMP ...
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[Regulation of BMP signaling].
Clinical calcium, 2006Bone morphogenetic proteins (BMPs), members of transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and -independent pathways. Intracellular signaling of BMPs is regulated by various modifiers and post-transcriptional modifications including ...
Takeshi, Imamura +2 more
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Recent advances in BMP receptor signaling
Cytokine & Growth Factor Reviews, 2009Bone Morphogenetic Proteins (BMPs) play an important role during organ development and during regeneration after tissue damage. BMPs signal via transmembrane serine/threonine kinase receptors. From our current understanding heteromeric complexes of type I and type II receptors are required for signal propagation.
Christina, Sieber +3 more
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