Results 121 to 130 of about 2,067 (154)
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2001
Boron-containing nucleosides are attractive agents for BNCT1 because they may be (1) taken up selectively into tumors due to the high mitotic rate of tumor cells vs. normal cells, (2) intracellularly converted to the corresponding nucleotides through phosphorylation by appropriate enzymes such as TK1 or dCK, and (3) possibly incorporated into tumor ...
Jin-Cong Zhuo +3 more
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Boron-containing nucleosides are attractive agents for BNCT1 because they may be (1) taken up selectively into tumors due to the high mitotic rate of tumor cells vs. normal cells, (2) intracellularly converted to the corresponding nucleotides through phosphorylation by appropriate enzymes such as TK1 or dCK, and (3) possibly incorporated into tumor ...
Jin-Cong Zhuo +3 more
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2015
Boron Neutron Capture Therapy-BNCT, constitutes an experimental form of a biochemically rather than a physically targeted type of radiotherapy and is mostly used in the treatment of high grade gliomas, such as GBM (Glioblastoma Multiforme). BNCT therapeutic effectiveness is based on two crucial steps: the selective accumulation of 10B, a ...
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Boron Neutron Capture Therapy-BNCT, constitutes an experimental form of a biochemically rather than a physically targeted type of radiotherapy and is mostly used in the treatment of high grade gliomas, such as GBM (Glioblastoma Multiforme). BNCT therapeutic effectiveness is based on two crucial steps: the selective accumulation of 10B, a ...
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1989
Some portion of the radiation dose received by a patient during BNCT consists of primary and secondary gammas. The biological effect of that portion of the dose will depend upon the time history of the delivered dose. The well-known models for relating time-dose effects to clinical experience, principally those of Orton1 and Ellis2 are of questionable ...
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Some portion of the radiation dose received by a patient during BNCT consists of primary and secondary gammas. The biological effect of that portion of the dose will depend upon the time history of the delivered dose. The well-known models for relating time-dose effects to clinical experience, principally those of Orton1 and Ellis2 are of questionable ...
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A physical dosimetry intercomparison for BNCT
Medical Physics, 2002An intercomparison of physical dosimetry methods used at the Massachusetts Institute of Technology (MIT) and Brookhaven National Laboratory was completed to enable retrospective analysis of BNCT trials. Measurements were performed under reference conditions pertinent to clinical irradiations at the epithermal neutron beam facility of the Brookhaven ...
Kent J, Riley +3 more
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Normalisation of prescribed dose in BNCT
Radiation Protection Dosimetry, 2007Normalisation of prescribed dose in boron neutron capture therapy (BNCT) is needed to facilitate combining clinical data from different centres in the world to help expedite development of the modality. The approach being pursued within the BNCT community is based upon improving precision in the measurement and specification of absorbed dose.
P J, Binns +4 more
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1992
The revival of BNCT over the last decade, stimulated the formation in 1987 of the European Collaboration group on BNCT. The multi-disciplinary nature of BNCT has drawn together groups of researchers from many European institutes who are now collaborating in an effort to achieve the implementation of BNCT in Europe at the earliest possible date.
R. L. Moss +4 more
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The revival of BNCT over the last decade, stimulated the formation in 1987 of the European Collaboration group on BNCT. The multi-disciplinary nature of BNCT has drawn together groups of researchers from many European institutes who are now collaborating in an effort to achieve the implementation of BNCT in Europe at the earliest possible date.
R. L. Moss +4 more
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BNCT Beam Quality Maximization
2001The Beam Shaping Assembly (BSA) optimization code SWAN is applied for establishing (1) the maximum attainable beam quality dependence on the BSA thickness; (2) the tradeoff between the maximum attainable beam quality and the dose-equivalent delivered, per source neutron, to the tumor; (3) the sensitivity of the above characteristics to the BSA ...
E. Greenspan, Y. Karni
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2001
If BNCT were performed in a single, unique facility and if its science were unique, concepts and terminology specific to this new modality could be developed. However, BNCT is a form of radiation therapy. To benefit from the vast accumulated experience with all types of radiation therapy and to ensure a common understanding and allow a fruitful ...
R. Gahbauer +5 more
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If BNCT were performed in a single, unique facility and if its science were unique, concepts and terminology specific to this new modality could be developed. However, BNCT is a form of radiation therapy. To benefit from the vast accumulated experience with all types of radiation therapy and to ensure a common understanding and allow a fruitful ...
R. Gahbauer +5 more
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Prescribing, Recording and Reporting of BNCT
2012In this chapter, recommendations for prescribing, recording and especially reporting of dose in BNCT are developed and discussed. The main goal of the authors was that these recommendations are coherent with the general rules of prescribing, recording and reporting of dose in conventional radiotherapy following international standards.
Rassow, Jürgen, Sauerwein, Wolfgang
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Neutronikaappaushoitoa kehitetään BNCT-asemalla
ATS Ydintekniikka, 2001Boorineutronikaappaushoitojen potilaskokeet on aloitettu toukokuussa 1999 FiR 1 -tutkimusreaktorin BNCT-asemalla. Toiminta tapahtuu Säteilyturvakeskuksen (STUK) NC-Hoito Oy:lle myöntämällä turvallisuusluvalla. Kohteena on pahanlaatuinen, primaari tai uusiutunut aivokasvain, glioblastoma multiforme.
Auterinen, Iiro, Kankaanranta, Leena
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