Results 111 to 120 of about 29,631 (205)

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li, Menglan Wang, Xiuhan Ye, Zhiyan Liu, Yijing Duan, Xiaoming Chen, Yue Ouyang, Qibiao Wu, Mengjuan Sun, Tian Xie   +9 more
wiley   +1 more source

Anaphylatoxin Complement 5a in Pfizer BNT162b2-Induced Immediate-Type Vaccine Hypersensitivity Reactions.

, 2023
: The underlying immunological mechanisms of immediate-type hypersensitivity reactions (HSR) to COVID-19 vaccines are poorly understood. We investigate the mechanisms of immediatetype hypersensitivity reactions to the Pfizer BNT162b2 vaccine and the ...
Justina Wei Lynn Tan (11634879), Kiat Hoe Ong (13846333), Bernard Yu Hor Thong (11674864), Kiat Hoe Ong, Ying Zhi Tan, Samuel Shang Ming Lee (11634895), Tan, Sarah Hui Zhen, Justina Wei Lynn Tan, Chua, Choon Guan, Claire Min Li Teo (15945161), Carol Yee Leng Ng, Choon Guan Chua, Choon Guan Chua (11977208), Tan, Justina Wei Lynn, Thong, Bernard Yu Hor, Tan, Guat Bee, Grace Yin Lai Chan (11634881), Teo, Claire Min Li, Bernard Pui Lam Leung, Lee, Samuel Shang Ming, Stephrene Seok Wei Chan (15945152), Leung, Bernard Pui Lam, Pui Lam Bernard Leung (10758753), Chan, Stephrene Seok Wei, Grace Yin Lai Chan, Carol Yee Leng Ng (11634876), Bernard Yu Hor Thong, Guat Bee Tan (12907730), Sarah Hui Zhen Tan (15945158), Stephrene Seok Wei Chan, Xin Rong Lim (11634873), Ying Zhi Tan (15945155), Chan, Grace Yin Lai, Xin Rong Lim, Samuel Shang Ming Lee, Lim, Xin Rong, Ng, Carol Yee Leng, Claire Min Li Teo, Guat Bee Tan, Tan, Ying Zhi, Sarah Hui Zhen Tan, Ong, Kiat Hoe   +41 more
core   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, Volume 22, Issue 26, 8 May 2026.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

Evaluation of BNT162b2 Vaccine Effectiveness in Galicia, Northwest Spain

, 2022
Investigating vaccine effectiveness (VE) in real-world conditions is crucial, especially its variation across different settings and populations. We undertook a test-negative control study in Galicia (Northwest Spain) to assess BNT162b2 effectiveness ...
Jacobo Pardo-Seco, Alberto Gómez-Carballa, Luis Ricardo López-Pérez, Benigno Rosón, Irene Rivero-Calle, Juan Manuel González-Pérez, Carmen Durán-Parrondo, Federico Martinón-Torres, María Teresa Otero-Barrós, Narmeen Mallah, Carmen Rodríguez-Tenreiro, Antonio Salas   +11 more
core   +1 more source

Herb‐Based Extracellular Vesicles for Infectious Disease

Small Structures, Volume 7, Issue 5, May 2026.
Chinese herbal medicine‐derived extracellular vesicles‐like particles (CHM‐EVLPs) are presented as innovative nanomedicines for infectious diseases. This review highlights their diverse therapeutic effects, including pathogen clearance, immune modulation, microbiota regulation and tissue barrier repairment, unlocking a powerful natural material against
Erjia Weng, Zhi‐Chao Sun, Yuntao Liu, Ran Liao, Ran Lin, Yan Zhang, Xi Zhang, Minghua Tang, Kaichun Yang, Xiaolu Wang, Wen Huang, Zhongde Zhang, Xiaotu Xi, Jun Wu   +13 more
wiley   +1 more source

Heterologous ChAdOx1 nCoV-19/BNT162b2 Prime-Boost Vaccination Induces Strong Humoral Responses among Health Care Workers

, 2021
Despite limited data on safety and immunogenicity, heterologous prime-boost vaccination is currently recommended for individuals with ChAdOx1 nCoV-19 prime immunization in certain age groups.
Florian Kälble, Christian Morath, Mirabel Buylaert, Julia Grenz, Paul Schnitzler, Maximilian Töllner, Christian Nusshag, Gerald Ponath, Caner Süsal, Katrin Klein, Martin Zeier, Claudius Speer, Louise Benning, Matthias Schaier, Asa Hidmark, Paula Reichel   +15 more
core   +1 more source

CoronaVac or BNT162b2 Vaccine as a Third Dose

American Journal of Respiratory and Critical Care Medicine, 2022
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit   +1 more
openaire   +2 more sources

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Kronik hemodiyaliz hastalarında bnt162b2 ve coronavac’a karşı hümoral yanıt: çok merkezli prospektif kohort çalışması

, 2022
Giriş: Kronik hemodiyaliz (HD) hastalarında SARS-CoV-2 için geliştirilmiş olan inaktif aşılara dair veriler hala sınırlıdır. Bu çalışmada, kronik HD hastalarında CoronaVac’ın uyardığı hümoral yanıtları BNT162b2 ile kıyaslayarak araştırmayı amaçladık ...
TUĞLULAR, ZÜBEYDE SERHAN, TUĞCU, MURAT   +1 more
core  

Immune-Mediated Thrombotic Thrombocytopenic Purpura after BNT162b2 Vaccine

Turkish Journal of Hematology, 2022
Tekin Guney, Ferda Can, Sema Akıncı, Özge Soyer Kösemehmetoğlu, İmdat Dilek   +4 more
doaj   +1 more source