Results 121 to 130 of about 29,631 (205)
Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism
Advanced Materials, Volume 38, Issue 22, 17 April 2026.Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa +16 morewiley +1 more sourceImmunogenicity and reactogenicity against the SARS-CoV-2 variants following heterologous primary series involving CoronaVac, ChAdox1 nCov-19 and BNT162b2 plus BNT162b2 booster vaccination: An open-label randomized study in healthy Thai adults
, 2022 We evaluated the immunogenicity and reactogenicity of heterologous COVID-19 primary schedules involving BNT162b2 (Pfizer-BioNTech), ChAdOx1 nCoV-19 (AstraZeneca) and CoronaVac (Sinovac) in healthy adults, as well as booster response to BNT162b2 following Jantraphakorn, Y, Jansarikit, L, Niyomnaitham, S, Mingngamsup, N, Wongprompitak, P, Licciardi, PV, Srisutthisamphan, K, Sapsutthipas, S, Chokephaibulkit, K, Quan Toh, Z +9 morecore +1 more sourceMechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
, 2022 Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show that immunization stimulated potent antibody Scott, Madeleine K. D., Wang, Yanli, Arunachalam, Prabhu S., Wimmers, Florian, Khatri, Purvesh, Scott, Madeleine K.D., Lee, Audrey, Feng, Yupeng, Kim, Peter, Sanyal, Mrinmoy, Luo, Wei, Valore, Erika, Nadeau, Kari C., Verma, Rohit, Weidenbacher, Payton A., Grigoryan, Lilit, Adamska, Julia Z., O’Hara, Ruth, Dunham, Diane, Pulendran, Bali, Park, Helen, Reis, Noah, Li, Chunfeng, Gitlin, Alexander D., Trisal, Meera +24 morecore +1 more sourceA Pilot Single-Blinded, Randomized, Controlled Trial Comparing BNT162b2 vs. JNJ-78436735 Vaccine as the Third Dose After Two Doses of BNT162b2 Vaccine in Solid Organ Transplant Recipients
, 2023 Solid Organ Transplant (SOT) recipients are at significant higher risk for COVID-19 and due to immunosuppressive medication, the immunogenicity after vaccination is suboptimal.Arosemena, Leopoldo, Sinha, Neeraj, Butrous, Hoda, Burke, George William, Morsi, Mahmoud, Simkins, Jacques, Guerra, Giselle, Pallikkuth, Suresh, Martin, Eric, Shobana, Sivan, Munagala, Mrudula R., Kupin, Warren Lee, Ciancio, Gaetano, Ortigosa-Goggins, Mariella, Sota, Katherine, Roth, David, Manickavel, Suresh, Bini, Julia, Natori, Yoichiro, Mattiazzi, Adela, Vianna, Rodrigo M., Anjan, Shweta, Phancao, Anita +22 morecore +1 more sourceClinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis
, 2022 Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here,Ran Talisman, Sumit Mukherjee, Mark Shlapobersky, Frenkel-Morgenstern, Milana, Cherniavsky, Evgenia, Detroja, Rajesh, Baum, Gideon, Shlapobersky, Mark, Mukherjee, Sumit, Dori, Amir, Milana Frenkel-Morgenstern, Eugene Merzon, Magen, Eli, Eli Magen, Mahua Bhattacharya, Evgenia Cherniavsky, Alejandro Livoff, Merzon, Eugene, Rajesh Detroja, Blum, Idan, Talisman, Ran, Livoff, Alejandro, Idan Blum, Amir Dori, Bhattacharya, Mahua, Gideon Baum +25 morecore +1 more sourceMyocarditis after BNT162b2 Vaccination in Israeli Adolescents
New England Journal of Medicine, 2022 Guy Witberg, Ori Magen, Sara Hoss, Yeela Talmor-Barkan, Ilan Richter, Maya Wiessman, Yaron Aviv, Tzlil Grinberg, Arthur Shiyovich, Nili Schamroth-Pravda, Oren Auster, Noa Dagan, Einat Birk, Ran Balicer, Ran Kornowski +14 moreopenaire +4 more sourcesHybrid immunity of the SARS-CoV-2 vaccine after the third doses in health workers
Revista Habanera de Ciencias MédicasIntroduction: Hybrid immunity is the immune response of people
infected with COVID-19 who received the SARS-CoV-2 vaccine. This
combination is more powerful than the immunity that is generated
after vaccination or infection alone.Raúl Montalvo, Kelina Almora-León, Anibal Diaz-Lazo, Jorge Montalvo, MÁ Tresierra-Ayala, Sharol Aliaga-Córdova +5 moredoaj Safety and Immunogenicity of the BNT162b2 Vaccine Coadministered with Seasonal Inactivated Influenza Vaccine in Adults
, 2023 Introduction: Vaccination is a critical tool for preventing coronavirus disease 2019 (COVID-19) and influenza illnesses. Coadministration of the COVID-19 vaccine, BNT162b2, with seasonal inactivated influenza vaccine (SIIV) can provide substantial ...S Bull (16141301), J Finlay (13420794), B Montgomery (13692898), T Humphrey (17352196), D Sheahan (17352208), M Williams (834184), E Esquilant (17352190), M Tagelagi (17352211), T Blackmore (17352187), AM Neville (17352205), J Kok (7737125), P Hamilton (9853613), J Kerr (13384890), WC Gruber (17352184), Ö Türeci (17352175), R Stubbs (16156847), S Smith (7655660), Y Zhang (5998940), Eugene Athan (13059501), C Lu (7742120), SP Lockhart (17352172), K Koury (17352169), D Quinn (13709203), U Şahin (17352178), L Murdoch (17352157), A Edwards (8842226), M Arya (9528248), D Cooper (9882962), K Quan (17352160), J Wojciechowska (17352217), AWY Ho (17352166), AS Anderson (14686159), KA Swanson (17352181), J Kamerbeek (17352199), A McGirr (17352202), X Xu (7070408), N Kitchin (9895364), C Thurlow (17352214), T Hemi (17352193), JA Baber (17352163) +39 morecore
