Results 111 to 120 of about 1,369,533 (295)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Corporate Governance Networks in Turkey [PDF]

open access: yes
We provide an analysis of corporate governance networks implied by members of board of directors of 319 companies listed in Istanbul Stock Exchange (ISE) for the year 2007.
Alper Duman, Efe Postalci
core  

Kualitas Papan Partikel Dari Campuran Ampas Tebu Dan Partikel Mahoni Dengan Berbagai Variasi Kadar Perekat Phenol Formaldehida [PDF]

open access: yes, 2015
The purpose of this study was to evaluate the effect of variations in the composition of bagasse and mahogany's particle with phenol formaldehyde adhesive variation levels on quality particle board also to determine the best treatment.
Hartono, R. (Rudi)   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

PENGUJIAN SIFAT FISIS-MEKANIS DAN NONDESTRUKTIF METODE GELOMBANG SUARA PAPAN WOL SEMEN BERKERAPATAN SEDANG-TINGGI BAMBU BETUNG (DENDROCALAMUS ASPER)

open access: yesJurnal Ilmu Pertanian Indonesia, 2012
Cement board is a composite wood product has advantages such as fire resistance, termite, water resistant, and has good sound insulation properties. Bamboo is suitable material that can be used as a raw material of cement board.
Lina Karlinasari   +4 more
doaj  

Pengaruh Compaction Ratio Terhadap Sifat Papan Lantai Partikel Kayu Jati Dan Sengon [PDF]

open access: yes, 2007
Wood particle board is one of building materials which can be used as floor like solid wood. To utilize particle boards with appropriate compaction ratio, study should be conducted to know the influence of compaction ratio on the particle board ...
Morisco, M. (Morisco)   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Utilização de madeiras de Eucalyptus grandis E Eucalyptus dunnii para produção de painéis de partículas orientadas – OSB

open access: yesCiência Florestal, 2008
This study was developed to evaluate the feasibility of OSB manufacturing using woods of Eucalyptus grandis and Eucalyptus dunnii. Boards with nominal density of 0,70 g/cm³ and 1,0 g/cm³ were manufactured in laboratory, using 100% of wood particles from ...
Setsuo Iwakiri   +3 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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