Results 121 to 130 of about 4,351,903 (305)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Material Development and Properties of Medium-Density Board from Low and High-Density Polyethylene

Advances in Technology Innovation
This study aims to develop a material from waste low-density polyethylene (LDPE) and high-density polyethylene (HDPE) into a medium-density board and assess its mechanical and physical properties. The development starts with degreasing the upcycled plastic sheets, stacking using premixed polyester resin as an adhesive, pressing, and laminating.
openaire   +1 more source

Minutes of the meeting of the Western Health Board 3rd December 1984

, 1985
Minutes of the regular Western Health Board meetings, held in ...
Western Health Board (WHB)
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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Other title: House Bill 2374 - Testimony on Behalf of the Citizens' Utility Ratepayer Board by David Springe, Consumer Counsel, Citizens' Utility Ratepayer Board

, 2003
application/pdf; "March 17, 2003."; Testimony before the Kansas Legislature, Senate Utilities Committee, presented by David Springe, Consumer Counsel, Citizens' Utility Ratepayer Board."CURB is strongly opposed to what H.B.
Springe, David.
core   +1 more source

Water-Related Properties and Biological Durability of Wood-Based Composites

Drvna Industrija
There is insufficient data regarding the biodegradation of wood-based composites (WBC) by wood decay fungi. This study aimed to evaluate the biological durability and water-related properties of different WBC types.
Ilze Irbe, Zanete Zommere, Juris Grinins
doaj   +1 more source

Understanding scopes of practice registered nurse, licensed practical nurse : highlights of the Ohio law and Board of Nursing rules.

, 2005
Title from p. [1] of PDF document (viewed Nov. 16, 2005).; "May 2005."; "Publication date: 06/05"--P. [12].; Harvested from the web on 11/17/05Clarifies and differentiates the scope of practice of the registered nurse (RN) and the licensed practical ...
Ohio Board of Nursing
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ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Agenda Book, Meeting of the Board of Visitors, February, 2015

, 2015
The Board of Visitors Agenda Book from the February 2015 meeting. The book includes Committee Meeting Schedule, Alumni Relations, Audit and Compliance, Athletics, Academic Affairs, Student Affairs, Administration, Buildings & Grounds ...
College of William and Mary. Board of Visitors
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