Results 81 to 90 of about 3,694,866 (341)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Asian Nursing Research, 2020
Purpose: Scoliosis is a common musculoskeletal problem in adolescents. This study aimed to identify the prevalence of adolescent idiopathic scoliosis (AIS) and its associated factors among Korean adolescents.
Suhee Kim, Ju-Yeon Uhm, Duck-Hee Chae, Yunhee Park   +3 more
doaj   +1 more source

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Nature, 2016
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances.
S. Wahl, A. Drong, B. Lehne, M. Loh, W. Scott, Sonja Kunze, P. Tsai, J. Ried, Weihua Zhang, Youwen Yang, Sili Tan, G. Fiorito, L. Franke, S. Guarrera, S. Kasela, J. Kriebel, R. Richmond, M. Adamo, U. Afzal, M. Ala-Korpela, B. Albetti, O. Ammerpohl, J. Apperley, M. Beekman, P. Bertazzi, S. Black, C. Blancher, M. Bonder, M. Brosch, M. Carstensen-Kirberg, A. D. de Craen, S. de Lusignan, A. Dehghan, M. Elkalaawy, K. Fischer, O. Franco, Tom R. Gaunt, J. Hampe, M. Hashemi, A. Isaacs, A. Jenkinson, S. Jha, N. Kato, V. Krogh, M. Laffan, C. Meisinger, T. Meitinger, Zuan Yu Mok, V. Motta, H. Ng, Z. Nikolakopoulou, Georgios Nteliopoulos, S. Panico, N. Pervjakova, H. Prokisch, W. Rathmann, M. Roden, F. Rota, M. A. Rozario, J. Sandling, C. Schafmayer, K. Schramm, R. Siebert, P. Slagboom, P. Soininen, L. Stolk, K. Strauch, E. Tai, L. Tarantini, B. Thorand, E. Tigchelaar, R. Tumino, A. Uitterlinden, C. V. van Duijn, J. V. van Meurs, P. Vineis, A. R. Wickremasinghe, C. Wijmenga, Tsun-Po Yang, Wei Yuan, A. Zhernakova, R. Batterham, G. Smith, P. Deloukas, B. Heijmans, C. Herder, A. Hofman, C. Lindgren, L. Milani, P. van der Harst, A. Peters, T. Illig, C. Relton, M. Waldenberger, M. Järvelin, V. Bollati, R. Soong, T. Spector, J. Scott, M. McCarthy, P. Elliott, J. Bell, G. Matullo, C. Gieger, J. Kooner, H. Grallert, J. Chambers   +106 more
semanticscholar   +1 more source

Health-related quality of life, adiposity, and sedentary behavior in patients with early schizophrenia: Preliminary study [PDF]

, 2012
Objective: To examine adiposity and sedentary behavior in relation to health-related quality of life (QoL) in patients with early schizophrenia. Methods: A cross-sectional study was used to assess adiposity by dual-energy X-ray absorptiometry scans ...
Brar, JS, Ganguli, R, Strassnig, M
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

BODY MASS INDEX AND BODY FAT CONTENT IN ELITE ATHLETES

Exercise and Quality of Life, 2011
The aim of this study was to evaluate body fat content (BF) of elite athletes obtained by two different field methods for body composition measurements and to compare it with body mass index (BMI) values.
Jelena Popadić Gaćeša, Otto Barak, Dae Karaba Jakovljevic, Aleksandar Klašnja, Vladimir Galiċ, Miodrag Drapšin, Damir Lukač, Nikola Grujić   +7 more
doaj   +1 more source

Defining Overweight and Obesity by Percent Body Fat Instead of Body Mass Index

Journal of Clinical Endocrinology and Metabolism
Objective Thresholds for overweight and obesity are currently defined by body mass index (BMI), a poor surrogate marker of actual adiposity (percent body fat [%BF]).
A. Potter, G. C. Chin, David P. Looney, K. E. Friedl   +3 more
semanticscholar   +1 more source

The Association between Body Mass Index and Premenstrual Syndrom among Female High School Students in Padang Lawas, North Sumatera [PDF]

, 2018
Background: Premenstrual syndrome (PMS) is a condition that affects a woman'semotions, physical health, and behavior during certain days of themens¬¬trual cycle, generally just before her menses.
Asfriyati, A. (Asfriyati), Hrp, C. M. (Cahayu ), Sanusi, R. (Rahayu )   +2 more
core  

Independent associations of TOMM40 and APOE variants with body mass index [PDF]

, 2019
The TOMM40-APOE variants are known for their strong, antagonistic associations with Alzheimer's disease and body weight. While a stronger role of the APOE than TOMM40 variants in Alzheimer's disease was suggested, comparative contribution of the TOMM40 ...
Arbeev, Konstantin G, Bagley, Olivia, Christensen, Kaare, Culminskaya, Irina, Feitosa, Mary F, Huang, Jian, Kulminski, Alexander M, Loika, Yury, Long Life Family Study Research Group,, Yashin, Anatoliy I, Zmuda, Joseph M   +10 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source