Results 81 to 90 of about 10,342,103 (300)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Body fat estimation in children by body mass index (BMI) [PDF]

, 2009
The body mass index (BMI) of adiposity should indicate the relative fatness of subjects of differing heights unless obesity is itself correlated with height. The practical advantages of BMI as a measure of obesity are obvious. Both body weight and height
Komiya, Shunichi, 607
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies [PDF]

, 2011
BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI),
Nordestgaard, Borge G., Stehouwer, Coen; id_orcid, Kaptoge, S., Danesh, J, Wood, Angela M., Thompson, Alex, Sattar, N, Thompson, A, Wormser, D, Emerging Risk Factors Collaboration, Risérus, Ulf,, Salomma, V, Sarwar, N, Danesh, J., Wood, Angela M, Pennells, L, Ärnlöv, Johan,, Woodward, M., Salomaa, Veikko, Sundström, Johan,, Thompson, S.G., Kaptoge, S, Tybjærg-Hansen, Anne, Wormser, D., Ridker, P, Thompson, Simon G, null The Emerging Risk Factors Collaboration, Woodward, Mark, Kizer, Jorge R, Frikke-Schmidt, Ruth, Nordestgaard, BG, Kaptoge, Stephen, Salomaa, V, Lawlor, DA, Eriksson, Henry,, Sarwar, Nadeem, Wood, AM, Kizer, Jorge R., Pennells, Lisa, Stevens, June, Pennells, L., Whitlock, G, Salomaa, V., Nordestgaard, B.G., Collins, Rory, Ridker, Paul, Thompson, A., Lawlor, D.A., Woodward, M, Collins, R, Kizer, J.R., Sattar, N., Lawlor, Debbie A, Sarwar, N., Ingelsson, Erik,, Davey Smith, George, Danesh, John, Stehouwer, Coen, Ridker, P., The Emerging Risk Factors Collaboration,, Di Angelantonio, Emanuele, Wood, A.M., Whitlock, G., Di Angelantonio, E., Sattar, Naveed, Lawlor, Debbie A., Collins, R., Di Angelantonio, E, Kizer, JR, Whitlock, Gary, Thompson, SG, Nordestgaard, Børge G, Stevens, J, Wormser, David, Stevens, J., Thompson, Simon G., Di Angeloantonio, Emanuele, Emerging Risk Factors Collaboration (Döring, A. ; Meisinger, C.)   +77 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Quantifying Obesity in Economic Research: How Misleading is the Body Mass Index? [PDF]

Replaced with revised version of paper 07/19/10.Obesity, percent body fat (PBF), body mass index (BMI), economic costs, measurement error, Health Economics and Policy, Research and Development/Tech Change/Emerging Technologies, C52, I10,
Smith, Aaron D., Parks, Joanna C., Alston, Julian M.   +2 more
core  

Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans [PDF]

, 2012
Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death.
Schiöth, H., Martin Klingenspor, Schiöth Helgi B., Fredriksson, Robert, Hölter, S.M., Josefin A. Jacobsson (177194), Klockars, A., Hrabě de Angelis Martin, Hrabě de Angelis, M., Sabine M Hölter, Rozman, Jane, Alsio, Johan, Kilimann, Manfred W., Siv Strömberg (177203), Martin Hrabě de Angelis, Wolfgang Wurst (712), Wurst, Wolfgang, de Angelis, M. H., Riserus, Ulf, Pawel K. Olszewski (177186), de Angelis, M., Kilimann, M., Klingenspor Martin, Alsiö Johan, Olszewski, P.K., Klopstock Thomas, Klopstock, T., Holter, Sabine, Rathkolb, B., Hölter, S. M., Jacobsson, Josefin A., Wurst, W., Alsiö, Johan,, Nicole Ehrhardt, Wolf Eckhard, Kilimann, M.W., Olszewski Pawel K., Kilimann Manfred W., Jan Rozman, Ralf Elvert, Ulf Risérus (177224), Hrabé de Angelis, Martin, Jacobsson, J. A., Wolf, E., Ehrhardt, Nicole, Elvert, Ralf, Becker, L., de Angelis, Martin Hrabě, Lore Becker (160172), Elvert, R., Wolfgang Hans (39864), Jacobsson Josefin A., Sabine M. Hölter (160170), Levine, Allen S., Klingenspor, Martin, Johan Alsiö, Risérus Ulf, Klockars, Anica,, Marcus, Claude, Jacobsson, Josefin A.,, Jacobsson, J.A., Claude Marcus, Anica Klockars (177212), Olszewski, P. K., Ehrhardt Nicole, Hölter, S., Hans, W., Schiöth, H. B., Birgit Rathkolb, Lore Becker, Ehrhardt, N., Valérie Gailus-Durner (125329), Klopstock, Thomas, Ulf Risérus, Fredriksson, R., Fuchs, Helmut, Ralf Elvert (177237), Gailus-Durner, Valerie, Wolfgang Wurst, Hölter Sabine M., Eckhard Wolf, Fuchs Helmut, Anica Klockars, Kilimann, Manfred W.,, Levine, A. S., Risérus, Ulf,, Thomas Klopstock, Levine, A.S., Helgi B Schiöth, Marcus Claude, Levine, A., Schiöth, H.B., Rathkolb, Birgit, Hans, Wolfgang, Robert Fredriksson (27811), Klockars, Anica, Manfred W Kilimann, Rozman, J., Rozman, Jan, Jan Rozman (149181), Olszewski, Pawel K.,, Hans Wolfgang, Helgi B. Schiöth (152210), Fuchs, H., Schiöth, Helgi B.,, Martin Hrabě de Angelis (2579524), Birgit Rathkolb (39867), Strömberg Siv, Manfred W. Kilimann (148306), Strömberg, Siv,, Valérie Gailus-Durner, Strömberg, S., Allen S Levine, Gailus-Durner, V., Helmut Fuchs, Claude Marcus (147851), Siv Strömberg, Eckhard Wolf (39870), Klockars Anica, Robert Fredriksson, Schiöth, Helgi B., Wurst Wolfgang, Kilimann, M. W., Elvert Ralf, Nicole Ehrhardt (177249), Fredriksson, Robert,, Josefin A Jacobsson, Alsiö, J., Olszewski, Pawel K., Johan Alsiö (177218), Jacobsson, J., Thomas Klopstock (160225), Martin Klingenspor (68144), Levine Allen S., Becker, Lore, Stromberg, Siv, Wolfgang Hans, Marcus, C., Helmut Fuchs (39863), Klingenspor, M., Fredriksson Robert, Rathkolb Birgit, Olszewski, P., Hoelter, Sabine M., Pawel K Olszewski, Allen S. Levine (177271), Gailus-Durner Valérie, Wolf, Eckhard, Becker Lore, Rozman Jan, Riserus, U., Riserus, U, Rozman, J, Alsio, J, Stromberg, S, Rathkolb, B, Hans, W, Olszewski, P.K. ; Rozman, J. ; Jacobsson, J.A. ; Rathkolb, B. ; Strömberg, S. ; Hans, W. ; Klockars, A. ; Alsiö, J. ; Risérus, U. ; Becker, L. ; Hölter, S.M. ; Elvert, R. ; Ehrhardt, N. ; Gailus-Durner, V. ; Fuchs, H. ; Fredriksson, R. ; Wolf, E. ; Klopstock, T. ; Wurst, W. ; Levine, A.S. ; Marcus, C. ; Hrabé de Angelis, M. ; Klingenspor, M. ; Schiöth, H.B. ; Kilimann, M.W., Becker, L, Olszewski, PK, M.W. Olszewski, P.K., Rozman, J., Jacobsson, J.A., Rathkolb, B., Strömberg, S., Hans, W., Klockars, A., Alsiö, J., Risérus, U., Becker, L., Hölter, S.M., Elvert, R., Ehrhardt, N., Gailus-Durner, V., Fuchs, H., Fredriksson, R., Wolf, E., Klopstock, T., Wurst, W., Levine, A.S., Marcus, C., de Angelis, M.H., Klingenspor, M., Schiöth, H.B., Kilimann,, Klockars, A, Olszewski, P. K.;Rozman, J.;Jacobsson, J. A.;Rathkolb, B.;Strömberg, S.;Hans, W.;Klockars, A.;Alsiö, J.;Risérus, U.;Becker, L.;Hölter, S. M.;Elvert, R.;Ehrhardt, N.;Gailus-Durner, V.;Fuchs, H.;Fredriksson, R.;Wolf, E.;Klopstock, T.;Wurst, W.;Levine, A. S.;Marcus, C.;de Angelis, M. H.;Klingenspor, M.;Schiöth, H. B.;Kilimann, M. W., Jacobsson, JA   +163 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Adjusted Measure of Body Mass Index for the Chinese and its Impact on Health [PDF]

The aim of this paper is to examine the impact of socio-economic status (SES) on the Body Mass Index (BMI), a formula based on the ratio of height to weight, linked to health, using a four-year (1991, 1993, 1997 and 2000) panel data set which comes from ...
Qiu, Tian
core