Results 91 to 100 of about 10,342,103 (300)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Demographic, Residential, and Socioeconomic Effects on the Distribution of 19th Century White Body Mass Index Values [PDF]

Little research exists on the body mass index values of 19th century Americans of European descent. Using a new BMI data set and robust statistics, between 1860 and 1880, BMIs decreased across the distribution; however, after 1880, BMIs in the highest ...
Scott A. Carson
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Body mass index as a standard of living measure: a different interpretation for the case of Colombia. [PDF]

We analyze the Body Mass Index (BMI) in a distinct way of its traditional use and it lets us use it as a proxy of standard of living for the case of Colombia. Our approach is focused on studying how far the people are from the normal range and not on the
Nohora Y. Forero Ramírez, Luis Fernando Gamboa   +1 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Adjusted Measure of Body Mass Index and its Impact on Health [PDF]

The aim of this paper is to examine the impact of socio-economic status (SES) on the Body Mass Index (BMI), a formula based on the ratio of height to weight, linked to health, using a four-year (1991, 1993, 1997 and 2000) panel data set which comes from ...
Qiu, Tian
core  

Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. [PDF]

, 2013
Objective To investigate the associations of body mass index (BMI) and grip strength with objective measures of physical performance (chair rise time, walking speed and balance) including an assessment of sex differences and non-linearity.
Hardy, R, John M. Starr (107707), McNeill Geraldine, Cooper, R, Kuh Diana, Rachel Cooper, Gallacher, John, Holly Syddall, Geraldine McNeill, Starr, John M., John Gallacher, Starr, John M, Yoav Ben-Shlomo, Aihie Sayer, Avan, McNeill, G, Ben-Shlomo, Y, Cyrus Cooper (141250), Panayotes Demakakos (196562), John Gallacher (196569), Martin, Richard M, Syddall Holly, Cyrus Cooper, Cooper Cyrus, Martin, RM, Hardy, Rebecca, Steptoe Andrew, McNeill, Geraldine, Demakakos, Panayotes, Demakakos Panayotes, Starr, JM, Syddall, H, Steptoe, A, ?, ?, John M Starr, HALCyon study team, Avan Aihie Sayer, Geraldine McNeill (107695), Cooper, Rachel, Deary, IJ, Ben-Shlomo, Yoav, Ian J. Deary (107724), Cooper Rachel, Avan Aihie Sayer (188916), Rebecca Hardy, Hardy Rebecca, Deary, Ian J., Martin, Richard M., Ian J Deary, Cooper, Cyrus, Holly Syddall (231862), Syddall, Holly, Richard M. Martin (176602), Sayer, Avan Aihie, Kuh, Diana, Rebecca Hardy (188906), Gallacher, J, Deary, Ian J, Panayotes Demakakos, Martin Richard M., Demakakos, P, Richard M Martin, Yoav Ben-Shlomo (95286), Andrew Steptoe, Diana Kuh, Gallacher John, Kuh, D, Starr John M., Andrew Steptoe (36331), Deary Ian J., Aihie Sayer, A, Cooper, C, Aihie Sayer Avan, Steptoe, Andrew, Ben-Shlomo Yoav, Diana Kuh (188923), Rachel Cooper (188902)   +75 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Factors Influencing the Body Mass Index of Adults in Canada [PDF]

This paper explores socio-demographic, economic and behaviour factors influencing body mass index (BMI) amongst 20 to 64 year old adults in Canada. BMI scores in Canada have increased, with gains stemming from disproportionate increases in female BMI ...
Cranfield, John A.L.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source