Results 101 to 110 of about 11,092,864 (299)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies [PDF]

, 2011
BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI),
Nordestgaard, Borge G., Stehouwer, Coen; id_orcid, Kaptoge, S., Danesh, J, Wood, Angela M., Thompson, Alex, Thompson, A, Wormser, D, Emerging Risk Factors Collaboration, Risérus, Ulf,, Salomma, V, Sarwar, N, Danesh, J., Wood, Angela M, Pennells, L, Ärnlöv, Johan,, Woodward, M., Salomaa, Veikko, Sundström, Johan,, Thompson, S.G., Kaptoge, S, Tybjærg-Hansen, Anne, Wormser, D., Ridker, P, Thompson, Simon G, null The Emerging Risk Factors Collaboration, Woodward, Mark, Kizer, Jorge R, Frikke-Schmidt, Ruth, Nordestgaard, BG, Kaptoge, Stephen, Lawlor, DA, Eriksson, Henry,, Sarwar, Nadeem, Wood, AM, Kizer, Jorge R., Pennells, Lisa, Stevens, June, Pennells, L., Whitlock, G, Salomaa, V., Nordestgaard, B.G., Collins, Rory, Ridker, Paul, Thompson, A., Lawlor, D.A., Woodward, M, Collins, R, Kizer, J.R., Sattar, N., Lawlor, Debbie A, Sarwar, N., Ingelsson, Erik,, Davey Smith, George, Danesh, John, Ridker, P., Di Angelantonio, Emanuele, Wood, A.M., Whitlock, G., Di Angelantonio, E., Sattar, Naveed, Lawlor, Debbie A., Collins, R., Di Angelantonio, E, Kizer, JR, Whitlock, Gary, Thompson, SG, Nordestgaard, Børge G, Stevens, J, Wormser, David, Stevens, J., Thompson, Simon G., Di Angeloantonio, Emanuele, Emerging Risk Factors Collaboration (Döring, A. ; Meisinger, C.), Tavendale, R., Nakamura, K., Bettencourt, R., Vartiainen, E., Noda, H., Tunstall-Pedoe, H., Ingelsson, E., Alexander, M., Björkelund, C., Lissner, L., Witteman, J., Jousilahti, P., Hillege, H.L., Tilvis, R.S., Umans, J., Blazer, D.G., Lowe, G.D.O., Chetrit, A., ørnlöv, J., Best, L., Pai, J.K., Franco, O.H., Nijpels, G., Koenig, W., Kitamura, A., Wingard, D.L., Ebrahim, S., Hofman, A., Vanuzzo, D., Yarnell, J., Poppelaars, J.L., Miettinen, T.A., Kiyohara, Y., Stehouwer, C.D.A., Giampaoli, S., Rosengren, A., Khaw, K.-T., Döring, A., Fox, C.S., Onat, A., Panico, S., Shaw, J.E., Dankner, H.R., Guralnik, J.M., Arima, H., Can, GÜNAY, Løchen, M.L., Welin, L., Yamagishi, K., Brunner, E., Kiechl, S., Wilsgaard, T., Bengtsson, C., Dekker, J.M., Phillips, C.L., Watson, S., Pencina, M.J., D’Agostino, R.B., Davidson, K.W., Deeg, D., Evans, A., Pilotto, L., Pitsavos, C., Shipley, M., Sato, S., Strandberg, T.E., Folsom, A.R., Barrett-Connor, E., Morris, R.W., Gobin, R., Mayr, A., Tiemeier, H., Gillum, R.F., Zhang, Y., Ninomiya, T., Gao, P., Palmieri, L., Iso, H., Kardys, I., Korin, M.R., Fletcher, A., De Boer, I.H., Chrysohoou, C., Barr, E.L.M., Verschuren, W.M.M., Frikke-Schmidt, R., Butterworth, A.S., Bakker, S.J.L., Whincup, P.H., Tybjærg-Hansen, A., Howard, B.V., Gallacher, J., Shea, S., Mathiesen, E.B., Arveiler, D., Atkins, R., Zimmet, P.Z., Bueno-De-Mesquita, H.B., Eriksson, H., Hankinson, S.E., Nakagawa, H., Njølstad, I., Buring, J., Mussolino, M., Kondapally Seshasai, S.R., Chambless, L.E., Nietert, P.J., Lubin, F., Panagiotakos, D.B., Mukamal, K.J., Keil, J.E., Wannamethee, S.G., Lewington, S., Rimm, E.B., Willeit, J., Walker, M., De La Cámara, A. Gómez, Wilhelmsen, L., Bachman, D.L., Psaty, B.M., Morikawa, Y., Blokstra, A., Sundström, J., Oberhollenzer, F., Harald, K., Wassertheil-Smoller, S., Sakurai, M., Stefanadis, C., Manson, J.E., Sutherland, S.E., Risérus, U., Svärdsudd, K., Ferrières, J., Amouyel, P., Meisinger, C., Gansevoort, R.T., Vasan, R.S., White, I.R., Rubio, M.A., Haycock, P., Lappas, G., Doi, Y., Shaffer, J.A., Hergenç, G., Kirkland, S.   +218 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The use of body mass index to predict body composition in children

, 2002
Background. Simple anthropometric indices of body composition have particular appeal for use in children, and as such body mass index (BMI) has been used to predict percentage body fat in a number of studies. Aim: To evaluate the relationship between BMI
Ball, EJ, Abbott, Rebecca, Baur, Louise, Davies, Peter, Davies, PSW, Wishart, C, O'Connor, Janice, O'Connor, J, Baur, LA, Ball, Elizabeth, Steinbeck, Kate, Gaskin, Kevin, Wishart, Connie, Gaskin, KJ, Abbott, RA, Steinbeck, KS   +15 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A comparison of measured height and demi-span equivalent height in the assessment of body mass index among people aged 65 years and over in England [PDF]

, 2008
Objectives: to examine differences between measured height and demi-span equivalent height (DEH) among people aged >= 65 and investigate the impact on body mass index (BMI) of using DEH.Design and Setting: nationally representative cross-sectional sample
Hirani, V, Mindell, J
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Effect Of Body Mass Index On Bone Mineral Density In Postmenopausal Women - Original Investigation [PDF]

, 2007
Aim: We aimed to determine the relationship between bone mineral density and body mass index in postmenopausal women. Material and Methods: 54 postmenopausal women were included in the study. Age and time of menopause were recorded. Smoking, alcohol and
Duygu Geler Külcü, Hakan Atalar, Derya Gökmen, Burcu Yanık   +3 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source