Results 51 to 60 of about 8,859,342 (293)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure [PDF]

Cell Metabolism, 2011
A human genome-wide linkage scan for obesity identified a linkage peak on chromosome 5q13-15. Positional cloning revealed an association of a rare haplotype to high body-mass index (BMI) in males but not females. The risk locus contains a single gene, "arrestin domain-containing 3" (ARRDC3), an uncharacterized α-arrestin.
Patwari, Parth, Emilsson, Valur, Schadt, Eric E., Chutkow, William A., Lee, Samuel, Marsili, Alessandro, Zhang, Yongzhao, Dobrin, Radu, Cohen, David E., Larsen, P. Reed, Zavacki, Ann Marie, Fong, Loren G., Young, Stephen G., Lee, Richard T.   +13 more
openaire   +2 more sources

Emotional regulation and self-perceived quality of life in high-performance mountain sports athletes

Frontiers in Psychology
Emotional regulation is an indispensable capacity for human beings, so that alterations in it can lead to the appearance of psychological, social and/or cognitive disorders. Therefore, possessing adequate emotional strategies is intimately related to the
Pablo Rojo-Ramos, Carmen Galán-Arroyo, Santiago Gómez-Paniagua, Antonio Castillo-Paredes, Jorge Rojo-Ramos   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Nonspecific Energy Expenditure of the Body and Body Mass Regulation

Journal of Nutritional Biology, 2019
The principal possibility of nonspecific energy expenditure at all stages of the transformation of nutrients in the body is demonstrated. These stages include the processing of food in the mouth, digestion, absorption, interaction with the intestinal micro biome, and interstitial metabolic processes.
openaire   +2 more sources

Body weight homeostat that regulates fat mass independently of leptin in rats and mice [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The only known homeostatic regulator of fat mass is the leptin system. We hypothesized that there is a second homeostat regulating body weight with an impact on fat mass. In this study we have added and removed weight loads from experimental animals and measured the effects on the biological body weight.
John-Olov Jansson, Vilborg Palsdottir, Daniel A. Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E. Johansson, Roger D. Cone, Daniel J. Drucker, Jianyao Wu, Biljana Aleksic, Anna E. Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H. Windahl, Claes Ohlsson   +18 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Studies on seasonal variation in metabolic rate related to changes in body composition with particular reference to shorebirds (Charadrii) [PDF]

, 1992
The basal metabolic rate of three species of shorebird was measured throughout the non-breeding season. These measurements were related to change in body mass and body composition.
Scott, Ian Alexander
core  

Effects of Exogenous Melatonin on Body Mass Regulation and Hormone Concentrations in Eothenomys miletus [PDF]

Journal of Stress Physiology & Biochemistry, 2013
By regulating the pineal hormone, photoperiods affect many physiological characteristics in small mammals. Thus, melatonin might take part in the thermoregulation of seasonal variations in small mammals.
Zhu, Wan-Long, Zhang, Di, Zhang, Lin, Wang, Zheng-Kun   +3 more
doaj