Results 61 to 70 of about 609,357 (298)

Body weight homeostat that regulates fat mass independently of leptin in rats and mice [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The only known homeostatic regulator of fat mass is the leptin system. We hypothesized that there is a second homeostat regulating body weight with an impact on fat mass. In this study we have added and removed weight loads from experimental animals and measured the effects on the biological body weight.
John-Olov Jansson, Vilborg Palsdottir, Daniel A. Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E. Johansson, Roger D. Cone, Daniel J. Drucker, Jianyao Wu, Biljana Aleksic, Anna E. Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H. Windahl, Claes Ohlsson   +18 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effects of Exogenous Melatonin on Body Mass Regulation and Hormone Concentrations in Eothenomys miletus [PDF]

Journal of Stress Physiology & Biochemistry, 2013
By regulating the pineal hormone, photoperiods affect many physiological characteristics in small mammals. Thus, melatonin might take part in the thermoregulation of seasonal variations in small mammals.
Zhu, Wan-Long, Zhang, Di, Zhang, Lin, Wang, Zheng-Kun   +3 more
doaj  

The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure [PDF]

Cell Metabolism, 2011
A human genome-wide linkage scan for obesity identified a linkage peak on chromosome 5q13-15. Positional cloning revealed an association of a rare haplotype to high body-mass index (BMI) in males but not females. The risk locus contains a single gene, "arrestin domain-containing 3" (ARRDC3), an uncharacterized α-arrestin.
Patwari, Parth, Emilsson, Valur, Schadt, Eric E., Chutkow, William A., Lee, Samuel, Marsili, Alessandro, Zhang, Yongzhao, Dobrin, Radu, Cohen, David E., Larsen, P. Reed, Zavacki, Ann Marie, Fong, Loren G., Young, Stephen G., Lee, Richard T.   +13 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Effect of sodium butyrate on diet-induced obesity in the Sprague-Dawley rat

浙江大学学报. 农业与生命科学版, 2015
Obesity has been reported as an increasingly prevalent and highly heritable health problem leading to increased risks for several common diseases. Human obesity can be induced by genetic factors such as loss-of-function mutations in individual genes. The
Zhu Han, Tan Shasha, Yang Hong, Wang Ling   +3 more
doaj   +1 more source

Non‐hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation [PDF]

Obesity, 2016
ObjectiveTo investigate the concurrent relationships between human plasma erythropoietin concentrations and energy expenditure (EE), body composition, plasma leptin concentrations, and associations with weight change.MethodsPlasma to measure erythropoietin and leptin; data for body composition; 24‐h EE measured in a whole‐room calorimeter; and 75 g ...
Martin, Reinhardt, Soumyadeep, Dey, Constance, Tom Noguchi, Yuanyuan, Zhang, Jonathan, Krakoff, Marie S, Thearle   +5 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Explaining individual variation in patterns of mass loss in breeding birds

, 2006
Background Studies of birds have a disproportionate representation in the literature on life-history evolution, because of the (apparent) ease with which the costs and benefits can be quantified and manipulated. During reproduction, birds frequently show
Alasdair I Houston, Rands, SA, Cuthill, IC, Sean A Rands, Innes C Cuthill, Houston, AI   +5 more
core   +1 more source