Results 81 to 90 of about 8,859,342 (293)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index [PDF]

, 2011
Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain.
Paternoster, Lavinia, Freathy, R.M., Jefferis, B. J., Johnson, P.C.D., Watt, G., Munafò, M, Ebrahim, S, Tozzi, F., Lawlor, D. A., Johnson, PC, Tozzi, Federica, Watt, Graham, Ebrahim, Shah, Ring, SM, Kring, S., Jefferis, BJ, C. Holst, Mooser, V, Tozzi, F, Hattersley, Andrew T, V. Mooser, Sorensen, T.I.A., A. T. Hattersley, Sørensen, Thorkild IA, Vollenweider, Peter, Ring, S.M., Kazeem, Gbenga R, Freathy, RM, Freathy, Rachel M, Hattersley, AT, Johnson, Paul CD, S. M. Ring, Whincup, PH, Whincup, P.H., Preisig, M, Sattar, N., Munafò, Marcus, Johnson, Paul C D, Lawlor, Debbie A, A. Hill, Hingorani, A.D., Jefferis, B.J., Vollenweider, P., S. I. I. Kring, Davey Smith, George, F. Tozzi, Ebrahim, S., Mooser, V., G. Waeber, Whincup, P. H., Hill, A, Jefferis, Barbara J, Morris, R. W., Mooser, Vincent, Whincup, Peter H, P. C. D. Johnson, Frayling, T. M., Sattar, Naveed, B. J. Jefferis, Kazeem, GR, Holst, Claus, Preisig, Martin, Kring, SI, Freathy, R. M., Sorensen, T. I. A., Watt, G, Hill, A., Ring, S. M., Padmanabhan, S, Davey Smith, G., Frayling, TM, G. Davey Smith, Upton, Mark N, Paternoster, L., Morris, Richard W, Waeber, Gerard, S. Ebrahim, Kring, S.I., Kring, Sofia I I, Sattar, N, Kring, Sofia II, L. Paternoster, Sørensen, TI, Hingorani, AD, Upton, M.N., D. A. Lawlor, T. M. Frayling, Hattersley, A.T., Hingorani, A. D., Preisig, M., Hattersley, A. T., Padmanabhan, S., Sorensen, Thorkild, T. I. A. Sorensen, Holst, C., Lawlor, DA, Holst, C, Waeber, G, Hingorani, Aroon D, Frayling, T.M., Padmanabhan, Sandosh, Waeber, G., Lawlor, D.A., A. D. Hingorani, Morris, RW, Sørensen, T.I., P. Vollenweider, G. R. Kazeem, Kazeem, G. R., Johnson, P.C., S. Padmanabhan, Upton, M. N., P. H. Whincup, R. W. Morris, Upton, MN, N. Sattar, Vollenweider, P, Ring, Susan M, Davey Smith, G, R. M. Freathy, M. Munafo, Sørensen, Thorkild I A, Munafo, M., Johnson, P. C. D., G. Watt, M. Preisig, Kazeem, G.R., Kring, S. I. I., Hill, Anita, Frayling, Timothy M, M. N. Upton, Paternoster, L, Kazeem, G.B., Morris, R.W.   +133 more
core   +1 more source

The Effect of Psychodrama on Body Mass Index, Self-Esteem and Cognitive Regulation of Emotion in Obese Female Children

Taḥqīqāt-i ̒Ulūm-i Raftārī, 2016
Aim and Background: The aim of this study was to investigate the effect of psychodrama on body mass index, self-esteem and cognitive emotion regulation in obese female children.
الهام شکرانه, حمیدطاهر نشاط دوست, محمدرضا عابدی, هوشنگ طالبی   +3 more
doaj  

Exploring the relationship between body appreciation and emotional regulation among Lebanese adults: The mediating role of psychological distress.

PLOS Global Public Health
Body appreciation is a key component of positive body image and contributes to psychological well-being. While difficulties in emotion regulation have been linked to negative body image and psychological distress, their association with body appreciation
Mohamad Alhourani, Nour Mhanna, Rania El Majzoub, Linda Abou-Abbas   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Nature Genetics, 2008
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000).
Willer, CJ, Speliotes, EK, Loos, RJ, Li, S, Lindgren, CM, Heid, IM, Berndt, SI, Elliott, Al, Jackson, AU, Lamina, C, Lettre, G, Lim, N, Lyon, HN, McCarroll, SA, Papadakis, K, Qi, L, Randall, JC, Roccasecca, Rm, Sanna, S, Scheet, P, Weedon, MN, Wheeler, E, Zhao, JH, Jacobs, LC, Prokopenko, I, Soranzo, N, Tanaka, T, Timpson, Nicholas John, Almgren, P, Bennett, A, Bergman, RN, Bingham, SA, Bonnycastle, LL, Brown, M, Burtt, NP, Chines, P, Coin, L, Collins, FS, Connell, JM, Cooper, C, Davey Smith, G, Dennison, EM, Deodhar, P, Elliott, P, Erdos, MR, Estrada, K, Evans, DM, Gianniny, L, Gieger, C, Gillson, CJ, Guiducci, C, Hackett, R, Hadley, D, Hall, AS, Havulinna, AS, Hebebrand, J, Hofman, A, Isomaa, B, Jacobs, KB, Johnson, T, Jousilahti, P, Jovanovic, Z, Khaw, KT, Kraft, P, Kuokkanen, M, Kuusisto, J, Laitinen, J, Lakatta, EG, Luan, J, Luben, RN, Mangino, M, McArdle, WL, Meitinger, T, Mulas, A, Munroe, PB, Narisu, N, Ness, A, Northstone, K, O'Rahilly, S, Purmann, C, Rees, MG, Ridderstråle, M, Ring, SM, Rivadeneira, F, Ruokonen, A, Sandhu, MS, Saramies, J, Scott, LJ, Scuteri, A, Silander, K, Sims, MA, Song, K, Stephens, J, Stevens, S, Stringham, HM, Tung, YC, Valle, TT, Van Duijn, CM, Vimaleswaran, KS, Vollenweider, P, Waeber, G, Wallace, C, Watanabe, RM, Waterworth, DM, Watkins, N, Wellcome Trust Case Control, Consortium, Witteman, JC, Zeggini, E, Zhai, G, Zillikens, MC, Altshuler, D, Caulfield, MJ, Chanock, SJ, Farooqi, IS, Ferrucci, L, Guralnik, JM, Hattersley, AT, Hu, FB, Jarvelin, MR, Laakso, M, Mooser, V, Ong, KK, Ouwehand, WH, Salomaa, V, Samani, NJ, Spector, TD, Tuomi, T, Tuomilehto, J, Uda, M, Uitterlinden, AG, Wareham, NJ, Deloukas, P, Frayling, TM, Groop, LC, Hayes, RB, Hunter, DJ, Mohlke, KL, Peltonen, L, Schlessinger, D, Strachan, DP, Wichmann, HE, McCarthy, MI, Boehnke, M, Barroso, I, Abecasis, GR, Hirschhorn, JN, Genetic Investigation of ANthropometric Traits, Consortium   +146 more
openaire   +9 more sources

Seasonal variation in body mass, body composition and activity-induced energy expenditure: a long-term study [PDF]

, 2020
Background/Objectives Seasonal variation in body mass is a model for the study of body mass regulation. Here a long-term study is presented on body mass, body composition, and activity-induced energy expenditure in a subject with a large seasonal ...
Klaas R. Westerterp, Westerterp, Klaas R.   +1 more
core   +1 more source

Effect of Cold Temperature and Food Restriction on Energy Metabolism and Thermogenesis in Eothenomys miletus [PDF]

Journal of Stress Physiology & Biochemistry, 2014
The aim of the present study was to examine the energy strategy in response to the cold temperature and food shortage. The survival rate, body mass, body fat content, serum leptin levels, basal metabolic rate (BMR) and nonshivering thermogenesis (NST) as
Wan-Long Zhu, Sheng-Chang Yang, Wen-Rong Gao, Lin Zhang, Zheng-Kun Wang   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The relationship between internet and smartphone addiction and body mass index: The mediating role of eating behaviors

Discover Public Health
This research was conducted determine the mediating role of eating habits in the effect of internet and smartphone addiction on body mass index. The study group consisted of 604 individuals aged between 18 and 45 years (Mean(Age) = 21.07, SD = 3.00 ...
Tuğba Türkkan, Kenan Bülbül, Hacı Ömer Yilmaz, Çağdaş Salih Meriç   +3 more
doaj   +1 more source