Results 91 to 100 of about 609,357 (298)
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Nature Genetics, 2008 Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000).Willer, CJ, Speliotes, EK, Loos, RJ, Li, S, Lindgren, CM, Heid, IM, Berndt, SI, Elliott, AL, Jackson, AU, Lamina, C, Lettre, G, Lim, N, Lyon, HN, McCarroll, SA, Papadakis, K, Qi, L, Randall, JC, Roccasecca, RM, Sanna, S, Scheet, P, Weedon, MN, Wheeler, E, Zhao, JH, Jacobs, LC, Prokopenko, I, Soranzo, N, Tanaka, T, Timpson, NJ, Almgren, P, Bennett, A, Bergman, RN, Bingham, SA, Bonnycastle, LL, Brown, M, Burtt, NP, Chines, P, Coin, L, Collins, FS, Connell, JM, Cooper, C, Smith, GD, Dennison, EM, Deodhar, P, Elliott, P, Erdos, MR, Estrada, K, Evans, DM, Gianniny, L, Gieger, C, Gillson, CJ, Guiducci, C, Hackett, R, Hadley, D, Hall, AS, Havulinna, AS, Hebebrand, J, Hofman, A, Isomaa, B, Jacobs, KB, Johnson, T, Jousilahti, P, Jovanovic, Z, Khaw, KT, Kraft, P, Kuokkanen, M, Kuusisto, J, Laitinen, J, Lakatta, EG, Luan, J, Luben, RN, Mangino, M, McArdle, WL, Meitinger, T, Mulas, A, Munroe, PB, Narisu, N, Ness, AR, Northstone, K, O'Rahilly, S, Purmann, C, Rees, MG, Ridderstråle, M, Ring, SM, Rivadeneira, F, Ruokonen, A, Sandhu, MS, Saramies, J, Scott, LJ, Scuteri, A, Silander, K, Sims, MA, Song, K, Stephens, J, Stevens, S, Stringham, HM, Tung, YC, Valle, TT, Van Duijn CM, Vimaleswaran, KS, Vollenweider, P, Waeber, G, Wallace, C, Watanabe, RM, Waterworth, DM, Watkins, N, Wellcome Trust Case Control Consortium, Witteman, JC, Zeggini, E, Zhai, G, Zillikens, MC, Altshuler, D, Caulfield, MJ, Chanock, SJ, Farooqi, IS, Ferrucci, L, Guralnik, JM, Hattersley, AT, Hu, FB, Jarvelin, MR, Laakso, M, Mooser, V, Ong, KK, Ouwehand, WH, Salomaa, V, Samani, NJ, Spector, TD, Tuomi, T, Tuomilehto, J, Uda, M, Uitterlinden, AG, Wareham, NJ, Deloukas, P, Frayling, TM, Groop, LC, Hayes, RB, Hunter, DJ, Mohlke, KL, Peltonen, L, Schlessinger, D, Strachan, DP, Wichmann, HE, McCarthy, MI, Boehnke, M, Barroso, I, Abecasis, GR, Hirschhorn, JN, Genetic Investigation of ANthropometric Traits Consortium +146 moreopenaire +7 more sourcesErythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara +12 morewiley +1 more sourceThe effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study
ObjectiveVariation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA).Pannoutsopoulou, K., Wheeler, M., Jones, G., Spector, T.D., Laslett, L.L., Cicuttini, F.M., Cooper, C., Metrustry, S., Zhang, W., Doherty, S., Arden, N.K., Doherty, M., Valdes, A.M., Zeggini, E., Maciewicz, R.A., Hart, D.J., Muir, K.R. +16 morecore +1 more sourceAssociation between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development [PDF]
, 2011 An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ...McCarthy, Mark I, Palmer, Colin N.A., Anneli Pouta, Yoav Ben-Shlomo, Warrington, N., Ann-Christine Syvänen, Cole, Tim, Mook-Kanamori, D.O. (Dennis), Lawrence Robert, Palmer, C., Vincent W V Jaddoe, Kaakinen, M, Palmer Lyle J., Palmer, Colin N. A., null null, Millwood, Iona Y., Laurent Briollais, Kaakinen, Marika, Tim J Cole, Johanna K Sandling, Palmer, Lyle, Palmer, CN, Davey Smith George, Craig E Pennell, Mook-Kanamori Dennis O., Briollais, L, Lawrence, R., Davey Smith, George, Palmer, Colin NA, Bennett, Amanda J, Palmer, Lyle J., Johanna K. Sandling, Timpson, Nicholas J, Nicole M. Warrington, Vincent W. V. Jaddoe, Sovio, U, Marika Kaakinen, Cole, Tim J, Palmer, C.N.A. (Colin), Jaddoe, Vincent W. V., Briollais, L., Amanda J. Bennett, Iona Y Millwood, Early Growth Genetics Consortium, Lawrence, R, Joanne Cecil, Cecil, J, Pouta, Anneli, Sandling, Johanna K., Smith, GD, Sovio, U. (Ulla), Lawrence, R.W. (Robert), Millwood, IY, Syvänen, Ann-Christine, Warrington, Nicole M., Timpson, Nicholas, Lawrie J. Beilin, Smith, G., Jaddoe, V., Cecil Joanne, Beilin, Lawrie J., Jarvelin, M-R, Craig E. Pennell, Laitinen Jaana, Nicole M Warrington, Mook-Kanamori, DO, Cole, T.J. (Tim), Mook-Kanamori, Dennis O., Järvelin Marjo-Riitta, et al., Pouta, A., Beilin, Lawrie J, McCarthy, MI, Lyle J Palmer, McCarthy Mark I., Pennell, Craig E., Mook-Kanamori, D., Warrington, N.M. (Nicole), Mark I. McCarthy, Davey Smith, G, Palmer Colin N. A., Cole, TJ, Warrington, Nicole M, Briollais Laurent, Molitor John, Jaddoe Vincent W. V., Pennell, C.E. (Craig), Briollais, Laurent, Dennis O. Mook-Kanamori, McCarthy, Mark I., John Molitor, for the EGG, Consortium, Palmer C N, A, Briollais, L. (Laurent), George Davey Smith, Jaddoe, VW, Jaddoe, VWV, Warrington Nicole M., Timpson, NJ, Molitor, J. (John), Nicholas J Timpson, Pennell, CE, Nicholas J. Timpson, Pennell, Craig E, Bennett, A.J. (Amanda), Dennis O Mook-Kanamori, Laitneen, J., Pouta, A, Sandling, JK, Molitor, J., Järvelin, Marjo-Riitta, Syvänen Ann-Christine, Cecil, Joanne Elizabeth, Millwood, Iona, Cole, Tim J., Smith, George Davey, McCarthy, Mark, Laitinen, J, Colin N. A. Palmer, Colin N A Palmer, Ben-Shlomo, Yoav, Jaana Laitinen, Kaakinen Marika, Sovio, U., Palmer, Lyle J, Robert Lawrence, Pennell Craig E., Kaakinen, M., Lawrence, Robert, Bennett, Amanda, Amanda J Bennett, Palmer, L., Jaddoe, Vincent WV, Sandling, J.K. (Johanna), Iona Y. Millwood, Beilin, Lawrie, Syvänen, Ann-Christine,, Mook-Kanamori, Dennis O, Pouta Anneli, Syvänen, A.-C., Bennett Amanda J., Sandling, J., Jaddoe, V.W.V. (Vincent), Sandling, Johanna K, Sovio Ulla, Beilin, LJ, Cecil, J., Bennett, Amanda J., Molitor, J, Palmer, LJ, Ben-Shlomo, Y., Lyle J. Palmer, Jaddoe, Vincent, Millwood, I., Beilin, L., Syvanen, A-C, Timpson Nicholas J., Jarvelin, MR, Bennett A, J, Järvelin, M.R., Sandling, Johanna, Lawrie J Beilin, Ben-Shlomo, Y, Beilin, L.J. (Lawrence), Syvanen, Ann-Christin, Bennett, AJ, Millwood, Iona Y, Laitinen, Jaana, Ulla Sovio, Bennett, A., Sovio, Ulla, Laitinen, J. (Jaana), Tim J. Cole, Millwood Iona Y., Timpson, Nicholas J., Smith, A.V. (Davey), Palmer, CNA, Cole Tim J., Mark I McCarthy, Mook, Dennis, McCarthy M, I, Cecil, Joanne, Pouta, A. (Anneli), Timpson, N.J. (Nicholas), Millwood, I.Y. (Iona), Beilin Lawrie J., Syvanen, A., Molitor, John, Pennell, Craig, Sandling Johanna K., Cecil, J. (Joanne), Sandling, Johanna K.,, Kaakinen, M. (Marika), Marjo-Riitta Järvelin, Warrington, NM, Ben-Shlomo Yoav, McCarthy, M.I. (Mark), Syvanen, AC, Palmer, Colin N. A.; id_orcid +198 morecore +1 more sourceThe behaviour of a neutral model of weight regulated only by body mass
Journal of Theoretical Biology, 2011 While there are many mechanisms that may be involved in the regulation of body mass in humans and other animals, it is not so clear how much regulation is needed beyond the negative feedback effect of body mass itself. Here we model weight changes as a stochastic process, and show that it behaves approximately as an autoregressive process.openaire +4 more sourcesExon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi +10 morewiley +1 more source
