Results 91 to 100 of about 1,492,384 (299)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Effect of Psychodrama on Body Mass Index, Self-Esteem and Cognitive Regulation of Emotion in Obese Female Children

Taḥqīqāt-i ̒Ulūm-i Raftārī, 2016
Aim and Background: The aim of this study was to investigate the effect of psychodrama on body mass index, self-esteem and cognitive emotion regulation in obese female children.
الهام شکرانه, حمیدطاهر نشاط دوست, محمدرضا عابدی, هوشنگ طالبی   +3 more
doaj  

Effect of Cold Temperature and Food Restriction on Energy Metabolism and Thermogenesis in Eothenomys miletus [PDF]

Journal of Stress Physiology & Biochemistry, 2014
The aim of the present study was to examine the energy strategy in response to the cold temperature and food shortage. The survival rate, body mass, body fat content, serum leptin levels, basal metabolic rate (BMR) and nonshivering thermogenesis (NST) as
Wan-Long Zhu, Sheng-Chang Yang, Wen-Rong Gao, Lin Zhang, Zheng-Kun Wang   +4 more
doaj  

Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation [PDF]

, 2012
Weight control diets favorably affect parameters of the metabolic syndrome and delay the onset of diabetic complications. The adaptations occurring in adipose tissue (AT) are likely to have a profound impact on the whole body response as AT is a key ...
Astrup, A. (Arne), Clement, K. (K.), Combes, M. (M.), Hager, J. (Jörg), Holst, C. (C.), Iacovoni, J.S. (J. S.), Langin, D. (D.), Maoret, J.J. (J.J.), Martinez, J.A. (José Alfredo), Montastier, E. (E.), Roussel, B. (B.), Saris, W.H.M. (Wim H. M.), Valle, C. (C.), Vidal, H. (Hubert), Viguerie, N. (N.), Villa-Vialaneix, N. (N.)   +15 more
core   +5 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Are Men More Intuitive When It Comes to Eating and Physical Activity?

American Journal of Men's Health, 2012
The purpose of this study was to determine where men fall on the motivation continuum based on intuitive eating status and if motivation for physical activity and intuitive eating are correlated.
Julie Gast PhD, MCHES, Hala Madanat PhD, Amy Campbell Nielson MS   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The relationship between internet and smartphone addiction and body mass index: The mediating role of eating behaviors

Discover Public Health
This research was conducted determine the mediating role of eating habits in the effect of internet and smartphone addiction on body mass index. The study group consisted of 604 individuals aged between 18 and 45 years (Mean(Age) = 21.07, SD = 3.00 ...
Tuğba Türkkan, Kenan Bülbül, Hacı Ömer Yilmaz, Çağdaş Salih Meriç   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source