Results 71 to 80 of about 602,092 (255)

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Nature Genetics, 2008
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000).
Willer, CJ, Speliotes, EK, Loos, RJ, Li, S, Lindgren, CM, Heid, IM, Berndt, SI, Elliott, Al, Jackson, AU, Lamina, C, Lettre, G, Lim, N, Lyon, HN, McCarroll, SA, Papadakis, K, Qi, L, Randall, JC, Roccasecca, Rm, Sanna, S, Scheet, P, Weedon, MN, Wheeler, E, Zhao, JH, Jacobs, LC, Prokopenko, I, Soranzo, N, Tanaka, T, Timpson, Nicholas John, Almgren, P, Bennett, A, Bergman, RN, Bingham, SA, Bonnycastle, LL, Brown, M, Burtt, NP, Chines, P, Coin, L, Collins, FS, Connell, JM, Cooper, C, Davey Smith, G, Dennison, EM, Deodhar, P, Elliott, P, Erdos, MR, Estrada, K, Evans, DM, Gianniny, L, Gieger, C, Gillson, CJ, Guiducci, C, Hackett, R, Hadley, D, Hall, AS, Havulinna, AS, Hebebrand, J, Hofman, A, Isomaa, B, Jacobs, KB, Johnson, T, Jousilahti, P, Jovanovic, Z, Khaw, KT, Kraft, P, Kuokkanen, M, Kuusisto, J, Laitinen, J, Lakatta, EG, Luan, J, Luben, RN, Mangino, M, McArdle, WL, Meitinger, T, Mulas, A, Munroe, PB, Narisu, N, Ness, A, Northstone, K, O'Rahilly, S, Purmann, C, Rees, MG, Ridderstråle, M, Ring, SM, Rivadeneira, F, Ruokonen, A, Sandhu, MS, Saramies, J, Scott, LJ, Scuteri, A, Silander, K, Sims, MA, Song, K, Stephens, J, Stevens, S, Stringham, HM, Tung, YC, Valle, TT, Van Duijn, CM, Vimaleswaran, KS, Vollenweider, P, Waeber, G, Wallace, C, Watanabe, RM, Waterworth, DM, Watkins, N, Wellcome Trust Case Control, Consortium, Witteman, JC, Zeggini, E, Zhai, G, Zillikens, MC, Altshuler, D, Caulfield, MJ, Chanock, SJ, Farooqi, IS, Ferrucci, L, Guralnik, JM, Hattersley, AT, Hu, FB, Jarvelin, MR, Laakso, M, Mooser, V, Ong, KK, Ouwehand, WH, Salomaa, V, Samani, NJ, Spector, TD, Tuomi, T, Tuomilehto, J, Uda, M, Uitterlinden, AG, Wareham, NJ, Deloukas, P, Frayling, TM, Groop, LC, Hayes, RB, Hunter, DJ, Mohlke, KL, Peltonen, L, Schlessinger, D, Strachan, DP, Wichmann, HE, McCarthy, MI, Boehnke, M, Barroso, I, Abecasis, GR, Hirschhorn, JN, Genetic Investigation of ANthropometric Traits, Consortium   +146 more
openaire   +9 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The relationship between internet and smartphone addiction and body mass index: The mediating role of eating behaviors

Discover Public Health
This research was conducted determine the mediating role of eating habits in the effect of internet and smartphone addiction on body mass index. The study group consisted of 604 individuals aged between 18 and 45 years (Mean(Age) = 21.07, SD = 3.00 ...
Tuğba Türkkan, Kenan Bülbül, Hacı Ömer Yilmaz, Çağdaş Salih Meriç   +3 more
doaj   +1 more source

The behaviour of a neutral model of weight regulated only by body mass

Journal of Theoretical Biology, 2011
While there are many mechanisms that may be involved in the regulation of body mass in humans and other animals, it is not so clear how much regulation is needed beyond the negative feedback effect of body mass itself. Here we model weight changes as a stochastic process, and show that it behaves approximately as an autoregressive process.
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Are Men More Intuitive When It Comes to Eating and Physical Activity?

American Journal of Men's Health, 2012
The purpose of this study was to determine where men fall on the motivation continuum based on intuitive eating status and if motivation for physical activity and intuitive eating are correlated.
Julie Gast PhD, MCHES, Hala Madanat PhD, Amy Campbell Nielson MS   +2 more
doaj   +1 more source

Roles of Ghrelin and Leptin in Body Mass Regulation under Food Restriction Based on the AMPK Pathway in the Red-Backed Vole, Eothenomys miletus, from Kunming and Dali Regions. [PDF]

Animals (Basel), 2022
Liu Y, Jia T, Ren Y, Wang Z, Zhu W.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Variations of Endocrine Hormones Concentrations in Tupaia belangeri under Simulated Seasonal Acclimatized: Role of Leptin Sensitivity [PDF]

Journal of Stress Physiology & Biochemistry, 2013
Seasonal variations in endocrine hormones concentrations are important for the survival of small mammals during acclimatization. In order to understand the role of leptin sensitivity on other endocrine hormones concentrations, we examined body mass ...
Zhu, Wan-long, Mu, Yuan, Zhang, Lin, Wang, Zheng-kun   +3 more
doaj