Results 81 to 90 of about 1,077,986 (305)

Increased intestinal carbonate precipitate abundance in the sea bream (Sparus aurata L.) in response to ocean acidification [PDF]

, 2019
Marine fish contribute to the carbon cycle by producing mineralized intestinal precipitates generated as by-products of their osmoregulation. Here we aimed at characterizing the control of epithelial bicarbonate secretion and intestinal precipitate ...
Carvalho, Edison S. M., Fuentes, Juan, Gregorio, Silvia, Ruiz-Jarabo, Ignacio   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance

Frontiers in Physiology, 2018
Obesity and lifestyle-related diseases are major problems faced by people in developed nations. Although exercise training prevents the progression of diabetes and obesity, the motivation for exercise is generally low in obese animals and humans.
Antonietta Messina, Marcellino Monda, Anna Valenzano, Giovanni Messina, Ines Villano, Fiorenzo Moscatelli, Giuseppe Cibelli, Gabriella Marsala, Rita Polito, Maria Ruberto, Marco Carotenuto, Vincenzo Monda, Andrea Viggiano, Aurora Daniele, Ersilia Nigro   +14 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Prinsip Umum Penatalaksanaan Cedera Olahraga Heat Stroke [PDF]

, 2016
Exercises that are conducted in an extreme heat environment can cause heat injury. Heatinjury is associated with disturbance to temperature regulation and cardiovascular systems. Heatstroke is the most severe type of heat injury.
Ade Tobing, Saharun Iso
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Effect of Brief Warming during Induction of General Anesthesia and Warmed Intravenous Fluid on Intraoperative Hypothermia in Patients Undergoing Urologic Surgery

Medicina
Background and Objectives: Transurethral urologic surgeries frequently lead to hypothermia due to bladder irrigation. Prewarming in the preoperative holding area can reduce the risk of hypothermia but disrupts surgical workflow, preventing it from being ...
Ye-Ji Oh, In-Jung Jun
doaj   +1 more source

Body temperature and its regulation

Anaesthesia & Intensive Care Medicine, 2014
Abstract Humans are homeotherms, i.e. they fix their temperature regardless of their environment. This is vital for normal cellular function and for metabolism to be independent of external temperature. The body has a warm ‘core’ and a cooler peripheral ‘shell’ whose role is to regulate heat transfer in and out of the core.
Kuht, J, Farmery, A
openaire   +2 more sources

Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in siberian hamsters [PDF]

, 2012
Peer reviewedPublisher ...
Amy Warner, Barrett, Bartness, Bechtold, Bernal, Braulke, Dentice, Dentice, Desouza, Duncan, Duncan, Dyess, Ebling, Ebling, Ebling, Ebling, Francis J. P. Ebling, Freeman, Hanon, Illnerová, John M. Brameld, Kanishka N. Nilaweera, Klieverik, Kokoeva, Kokoeva, Kong, Köhrle, Lincoln, Lincoln, López, Michelle Murphy, Morgan, Morgan, Nakao, Perry Barrett, Preeti H. Jethwa, Revel, Ruby, Sjögren, Warner, Watanabe, Xiong, Xu, Yasuo, Yoshimura, Zoeller, Zoeller   +46 more
core   +1 more source