Results 71 to 80 of about 159,392 (359)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Experimental analysis of bolts employed as shear connectors in circular concrete-filled tube columns
Revista IBRACON de Estruturas e Materiais, 2019 This paper presents experimental and theoretical analysis of bolts employed as shear connectors in circular concrete-filled steel tube columns (CFTs).
E. M. XAVIER +4 more
doaj +2 more sources
Góry, Literatura, Kultura, 2021 The first bolts in Poland were fixed in Góry Sokole (Falcon Mountains). This was a climbing technique which became a turning point in rock climbing and changed the ethical framework of mountaineering. The first device for fixing bolts was developed by Tadeusz Zipser, a young mountaineer and graduate of the Wrocław University of Science and Technology ...
openaire +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
quas ... pro summis in utroque iure honoribus ac privilegiis doctoralibus post actum disputatorium rite consequendis ad diem 31. Augusti M DCC LXXXI. ... publicae disquisitioni submittit. Iohannes Casparus Bolt ToggiusEnthält 9 ThesenDiss. iur.
Bolt, Johann Kaspar
core +1 more source
, 2013 The truss bolt reinforcement system has been used in controlling the stability of underground excavations in severe ground conditions and cutter roof failure in layered rocks especially in coal mines.
Ghabraie, Kazem +3 more
core +1 more source
Stress-strain analysis and safety check during arc discharge in UHV transformers
Zhejiang dianliArc discharge caused by short-circuit faults is one of the most serious faults in UHV transformers， with the potential for inducing deformation， rupture， burning， or even explosion of the oil tank.
ZHU Qingdong +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source