Results 141 to 150 of about 24,376 (300)

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

open access: yesiMetaOmics, EarlyView.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo   +9 more
wiley   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

open access: yesiNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi   +14 more
wiley   +1 more source

Caste as a Social Kind

open access: yesJournal of Applied Philosophy, EarlyView.
ABSTRACT Gender and race have received significant philosophical attention recently; they are the paradigm cases of social kinds in most philosophical accounts. I argue for the inclusion of caste as a social kind because it affects the lives of many people, and because it presents itself as an important test case for philosophers of social kinds.
Ajinkya Deshmukh
wiley   +1 more source

The Southern California Healthcare Delivery Science Center: A Model for Aligning Patients, Healthcare Systems, and Researchers to Develop, Test, and Disseminate Innovations to Achieve Health Equity

open access: yesLearning Health Systems, EarlyView.
ABSTRACT Introduction A key barrier to translating evidence into practice is the paucity of learning health system (LHS) researchers elucidating and addressing barriers to implementation and maintenance. Methods In response to the growing need for a workforce dedicated to translating evidence into practice, we developed the Southern California ...
Amytis Towfighi   +4 more
wiley   +1 more source

FanFAIR: sensitive data sets semi-automatic fairness assessment. [PDF]

open access: yesBMC Med Inform Decis Mak
Gallese C   +4 more
europepmc   +1 more source

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

open access: yesMovement Disorders, EarlyView.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark   +8 more
wiley   +1 more source

Pearls for Starting a Headache Surgery Practice in Academic and Private Practice. [PDF]

open access: yesJPRAS Open
Saad M   +6 more
europepmc   +1 more source

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