Results 41 to 50 of about 24,376 (300)
Advanced Science, EarlyView.In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong +11 more
wiley +1 more source
Wetenskap met en sonder diepte?
Koers : Bulletin for Christian Scholarship, 2006 Science with and without depth? In trying to understand science in interaction with its presuppositions, values and bona fides, an overview of three different but closely related dimensions or layers or zones of science present in the functioning of ...
P.G.W. du Plessis
doaj +1 more source
Budget support, conditionality and poverty [PDF]
, 2005 This paper examines the effectiveness of budget support aid as an anti-poverty instrument. We argue that a major determinant of this effectiveness is the element of trust – or `social capital´, as it may be seen – which builds up between representatives ...
Mosley, P., Suleiman, A.
core
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Russian Journal of Economics and Law, 2011 The article deals with such issues as moral grounds of Roman law, significance and role of aequitas (fairness) principle, such categories as bona fides (good faith), infamia (bad reputation), iniuria (personal insult, offence).
K. Ugurchiyeva
doaj
The principle of reliance on real estate records and acquisition of ownership by usucapio on immovables: Part two [PDF]
Zbornik Radova Pravnog Fakulteta u NišuUsucapio (acquisitive prescription or adverse possession) ultimately brings the factual and legal situation in accord by "turning" a long-term possession that was incompatible with ownership into legal ownership (title to property).
Lazić Miroslav
doaj +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
O PENSAMENTO JUSNATURALISTA NO DIREITO ROMANO
Direito e Desenvolvimento, 2017 Em Roma, o pensamento jusnaturalista é fortemente tributário da filosofia estoica. Todavia, os jurisconsultos romanos nunca puseram o problema da lei injusta, porque, para eles, o direito é sempre “ars boni ae aequi”.
António dos Santos Justo
doaj
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, EarlyView.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source