Results 61 to 70 of about 24,376 (300)
Potchefstroom Electronic Law Journal, 2019 In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj +1 more source
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, EarlyView.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Carter v Boehm: facts and context [PDF]
, 2016 There is a curious irony in the lawsuit Carter v Boehm. The final decision of the Court of King’s Bench, delivered by Chief Justice Mansfield at Easter 1766, famously articulated the principle of uberrima fides (utmost good faith), which became the ...
Pearson, Robin
core
Advanced Science, EarlyView.This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong +13 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
African Studies QuarterlyBecause of the determined effort of the anti-apartheid movement to secure South Africa’s expulsion from the international sports arena, the Bureau of State Security (BOSS) established the Committee for Fairness in Sport (CFFS) in 1973.
Hendrik Snyders
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Trust Strategies for the Semantic Web [PDF]
, 2004 Everyone agrees on the importance of enabling trust on the SemanticWebto ensure more efficient agent interaction. Current research on trust seems to focus on developing computational models, semantic representations, inference techniques, etc.
Alani, Harith +3 more
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Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source
A crowd of Gods: atheism and superstition in Juvenal Satire 13 [PDF]
, 2019 Accepted ...
Uden, James
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