Results 71 to 80 of about 24,376 (300)
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Revista de Derecho (Coquimbo), 2016 El presente trabajo tiene por objeto el análisis crítico de la regulación que el ordenamiento jurídico chileno establece con respecto al fraude de seguros.
Laura Mayer Lux, Lorena Carvajal Arenas
doaj
Physiological Demands of Common Occupational Tasks among Australian Police Officers: A Descriptive Analysis. [PDF]
Ann Work Expo Health, 2022 Decker A +4 more
europepmc +1 more source
Drepturile culturale bona fide ale migranților//Bona fide Migrants’ Cultural Rights
Analele Ştiinţifice ale Universităţii "Al.I. Cuza" din Iaşi. Ştiinţe Juridice, 2021 In the general context of social transformations within the international community, the phenomenon of migration holds attention through the special impact it has on all members of the community, regardless of the nationality of those who interact at the social level.
openaire +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Book Review: The Orthodox Church in Ukraine: A Century of Separation
, 2020 “Fog of war” commonly names the complete lack of situational awareness amidst a singular lethal engagement, but it may also describe the absence of clarity regarding the foundational reasons, societal dimensions, and collateral impact of years of ...
Loya, Joseph
core
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Czasopismo Prawno-Historyczne, 1967 La distinction des effects de l’erreur de fait et des effets de l’erreur de droit a son origine dans la jurisprudence romaine classique. Le règle transmise par Paulus (D. 22.6.9.
Witold Wołodkiewicz
doaj +1 more source
Warning: Humans cannot reliably detect speech deepfakes. [PDF]
PLoS One, 2023 Mai KT, Bray S, Davies T, Griffin LD.
europepmc +1 more source
Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination
Advanced Science, EarlyView.Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi +21 more
wiley +1 more source