Results 81 to 90 of about 24,376 (300)
Synergistic Mn‐MOF Activation of Pistol Ribozymes for Cancer Immunotherapy
Advanced Science, EarlyView.A Mn2+‐based metal–organic framework delivers a catalytic Pistol ribozyme for targeted PD‐L1 mRNA cleavage in tumor cells, with the released Mn2+ not only inducing immune activation in immune cells but also increasing the Pistol ribozyme catalytic activity.
Ming Zhao +10 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang +5 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Community-based conservation: Intrinsic versus extrinsic values
Contree, 2006 This article commences with an examination of the reasons for the enormous increase in areas under state protection worldwide, and proceeds to discover two incompatible value systems that inform this expansion.
Mark Ingle
doaj +1 more source
Real masks and spoof faces: On the masked face presentation attack detection. [PDF]
Pattern Recognit, 2022 Fang M +3 more
europepmc +1 more source
Advanced Science, EarlyView.Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu +9 more
wiley +1 more source
Globalization and Health, 2019 Background Sugar sweetened beverages (SSB) are a major source of sugar in the diet. Although trends in consumption vary across regions, in many countries, particularly LMICs, their consumption continues to increase.
Gary Jonas Fooks +3 more
doaj +1 more source
Literature review of research into attitudes towards electronic theses and dissertations (ETDs) [PDF]
, 2010 This document summarises existing research into the attitudes of graduate students and their supervisors towards electronic theses and dissertations (ETDs). Research was identified from Germany, India, Italy, South Africa, the UK and the US.
Brown, J.
core +1 more source
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Advanced Science, EarlyView.Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source