Results 91 to 100 of about 386,628 (313)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Chemical bonding at surfaces and interfaces / [PDF]
, 2008 Molecular surface science has made enormous progress in the past 30 years. The development can be characterized by a revolution in fundamental knowledge obtained from simple model systems and by an explosion in the number of experimental techniques.
Nilsson, Anders. +2 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Clusters and case vignettes of impaired maternal–fetal bonding in pregnancy: A mixed method approach
PCN ReportsAim Clinical attention to and understanding of women with impaired fetal bonding is important for early therapeutic intervention. This study aimed to clarify the clinical characteristics of women belonging to groups derived by cluster analysis of ...
Toshinori Kitamura +3 more
doaj +1 more source
Fracture of Ag sintering bonding interface on active metal brazing substrates for power electronics
Results in Surfaces and InterfacesThis study investigated the effects of Cu and Ag surface treatments on active metal brazing (AMB) substrates from two manufacturers (A and B) with respect to the sintered bonding characteristics of Ag paste and film.
Jeeyeon Park +5 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
STUDY ON THE FORMATION MECHANISM OF BONDING LAYER AROUND PILE BODY IN SOFT CLAY
Civil Engineering Journal, 2019 After jacked pile is driven into the soft clay,a bonding layer would form a around pile body,it enlarges the pile side area and increases its bearing capacityeffectively.
Jiang Yue-Nan, Chen Song
doaj +1 more source
Natural Fragment Bond Orbital Method for Inter-Fragment Bonding Interaction Analysis [PDF]
A complex chemical system is often examined based on their fragments, so fragment-based analysis is the key to chemical understanding. We report the natural fragment bond orbital (NFBO) method for inter-fragment bonding interaction analysis, as an ...
Fu Kit, Sheong +2 more
core +1 more source