Results 71 to 80 of about 6,066,361 (406)

The unbearable lightness of bone marrow homeostasis [PDF]

, 2015
The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS, Douni E., MARCHETTI, Luigi, SABBIETI, Maria Giovanna   +3 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

The Performativity of Qualitative Social Research

Forum: Qualitative Social Research, 2011
Within the last two decades qualitative social research has established itself in most, if not all, of the social sciences. But this emergence has proceeded very differently in institutional and in socio-cognitive aspects.
Rainer Diaz-Bone
doaj  

Pelatihan Pembuatan Website Desa dengan Media Google Sites

Madaniya
Google Sites dibuat agar memudahkan penggunanya walaupun tidak berlatar belakang di bidang teknologi informasi untuk memahami pengoperasiannya dalam waktu singkat sehingga penggunanya dapat mengembangkan website yang sederhana sesuai dengan fungsinya ...
Fahriadi Muhdar, Taufik Hidayah, Nurul Shafira, Melie Apisa, Muh. Fadli, Dias Nur Astisya, Surianti Surianti, Elys Elys   +7 more
doaj   +1 more source

Targeting cellular senescence prevents age-related bone loss in mice

Nature Network Boston, 2017
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In particular,
J. Farr, Ming Xu, Megan M. Weivoda, D. Monroe, Daniel G. Fraser, Jennifer L Onken, Brittany A Negley, J. Sfeir, M. Ogrodnik, Christine M. Hachfeld, N. LeBrasseur, M. Drake, R. Pignolo, T. Pirtskhalava, T. Tchkonia, M. Oursler, J. Kirkland, S. Khosla   +17 more
semanticscholar   +1 more source

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Abstinence and alcohol consumption among secondary school students

INFAD, 2014
A young person tend to drink alcohol due to the curiosity, imitation belonging to a peer group and in some cases the motivation of the family. Alcohol is therefore socially tolerated moderate alcohol consumption can lead risk forms of consumption.
Jorge Bonito, María Boné
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Karyotype abnormalities and their clinical significance in a group of chronic myeloid leukemia patients treated with hematopoietic stem cell transplantation

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Following hematopoietic stem cell transplantation (HSCT), karyotyping is a valuable tool for monitoring engraftment and disease status.
Luize Otero, Maria Helena Ornellas, Alexandre Mello de Azevedo, Rita de Cássia Tavares, Virgínia Pires, Eliana Abdelhay, Luis Fernando Bouzas, Teresa de Souza Fernandez   +7 more
doaj   +1 more source