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Osteoclasts prefer aged bone

Osteoporosis International, 2007
We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.Osteoclasts resorb aging bone in order to ...
Henriksen, K   +9 more
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Age changes in bone

Gerodontology, 1998
AbstractChanges in bone structure as a function of age have been studied by simple inspection, x‐ray imaging, stereo‐photography, deep field optical microscopy, circularly polarised light microscopy, and scanning electron microscopy (SEM), including both topographic and compositional backscattered electron (BSE) imaging modes.
A, Boyde, V J, Kingsmill
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Aging of the Bone

2018
Besides mechanical and protective function, bone serves as a keeper for marrow cells and an organ for regulation of calcium ion homeostasis. During aging, significant amounts of the bone are lost due to the loss of this delicate balance toward increased bone resorption coupled with decreased formation, which leads to net bone loss of the aging people ...
Yu, Wei, Yao, Sun
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On Aging Bone Loss

Clinical Orthopaedics and Related Research, 1982
A survey was done of aging changes in compact and trabecular bone. During the past decade, noninvasive methods have demonstrated similar results for compact bone in large samples. Aging decreases of 3%/decade begin at about age 40 in both sexes and continue, but in women, an additional loss occurs after menopause, bringing their total rate of decrease ...
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Age-related bone changes

Experimental Gerontology, 1991
Bone changes occur during normal aging in both men and women. Changes are both quantitative and qualitative in nature, and include: 1) alterations in the dynamics of bone cell populations, resulting in uncoupling of the normal process of bone resorption and formation; 2) changes in bone architecture (e.g., rearrangement of trabecular struts) and cross ...
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Exercise, Age, and Bones

Southern Medical Journal, 1994
Skeletal development in average healthy individuals is maximal at age 25 in women and at age 30 to 35 in men. However, there are significant racial differences, skeletal mass being greater in black than in white individuals. This difference appears best accounted for by increased muscle mass in blacks.
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Bone and fat connection in aging bone

Current Opinion in Rheumatology, 2008
The fat and bone connection plays an important role in the pathophysiology of age-related bone loss. This review will focus on the age-induced mechanisms regulating the predominant differentiation of mesenchymal stem cells into adipocytes. Additionally, bone marrow fat will be considered as a diagnostic and therapeutic approach to osteoporosis.There ...
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Aging of bone

Reviews in Clinical Gerontology, 1998
In Europe, vertebral fracture incidence has increased 300–400% for women and more than 400% for men during the last 30 years. These data are age-adjusted and therefore highlight that there is a decrease in bone mass or bone quality from generation to generation.
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Bone Aging

1975
U J, Schmidt, I, Kalbe, F, Sielaff
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Restoring Aging Bones

Scientific American, 2003
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