Results 41 to 50 of about 237,648 (288)

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

npj Regenerative Medicine
Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular cartilage degradation and inflammation, leading to joint pain and disability.
Hongshang Chu, Shaoyang Zhang, Zhenlin Zhang, Hua Yue, Huijuan Liu, Baojie Li, Feng Yin   +6 more
doaj   +1 more source

Neonatal Diabetes, Congenital Hypothyroidism, and Congenital Glaucoma Coexistence: A Case of GLIS3 Mutation

JCRPE, 2023
Neonatal diabetes and congenital hypothyroidism (CH) syndrome is a rare condition caused by homozygous or compound heterozygous mutations in the GLIS3 gene.
Emre Sarıkaya, Mustafa Kendirci, Mikail Demir, Munis Dündar   +3 more
doaj   +1 more source

Botpathologie bij apen van de Nieuwe en Oude Wereld [PDF]

, 2015
Primates are frequently used lab animals in biomedical research, due to their close relationship to humans. Especially, the genus Callithrix jacchus (common marmoset) and the genus Macaca mulatto (rhesus monkey) are commonly used in scientific research ...
Bakker, J, Bosseler, Leslie, Chiers, Koen, Cornillie, Pieter, Decostere, Annemie, Langermans, J, Molenberghs, Freya, Saunders, Jimmy   +7 more
core  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

eLife
Elastic cartilage constitutes a major component of the external ear, which functions to guide sound to the middle and inner ears. Defects in auricle development cause congenital microtia, which affects hearing and appearance in patients.
Ruichen Yang, Hongshang Chu, Hua Yue, Yuji Mishina, Zhenlin Zhang, Huijuan Liu, Baojie Li   +6 more
doaj   +1 more source

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

Experimental and Molecular Medicine, 2023
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties.
Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +17 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Failure of dental implants in cemento-osseous dysplasia: a critical analysis of a case

Revista de Odontologia da UNESP
Introduction: Osseointegrated dental implants have been routinely used in oral rehabilitation. Patients with dysplastic bone diseases represent a particular challenge for oral rehabilitation with dental implants.
Maiolino Thomaz Fonseca OLIVEIRA, Sérgio Vitorino CARDOSO, Cláudia Jordão SILVA, Darceny ZANETTA-BARBOSA, Adriano Mota LOYOLA   +4 more
doaj   +1 more source

A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome. [PDF]

, 2019
BackgroundAngelman syndrome (AS) is a neurodevelopmental disorder that is caused by maternal genetic deficiency of a gene that encodes E6-AP ubiquitin-protein ligase (gene symbol UBE3A) mapping to chromosome 15q11-q13.
Anselm, Irina, Bacino, Carlos A, Bichell, Terry Jo, Bird, Lynne M, Golden, Stephanie, Han, Julia, Kimonis, Virginia, Peters, Sarika U, Waisbren, Susan   +8 more
core  

Psychiatric characterization of children with genetic causes of hyperandrogenism [PDF]

, 2010
Objective: Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group. Design/methods: Children (8-18 years) with the diagnosis of classic
Ernst, Monique, Green-Golan, Liza, Leschek, Ellen, Merke, Deborah, Müller, Sven, Ng, Pamela, Sinaii, Ninet, VanRyzin, Carol   +7 more
core   +2 more sources