Results 61 to 70 of about 12,008,318 (406)

HIF-1α Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases

Cells, 2022
In the physiological condition, the skeletal system’s bone resorption and formation are in dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under pathological conditions, leading to the occurrence of bone metabolism ...
Wei Chen, Panfeng Wu, Fang Yu, Gaojie Luo, Li-ming Qing, Ju-yu Tang   +5 more
semanticscholar   +1 more source

The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition “Killing Two Birds with One Stone”?

Cells, 2019
Nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of various genes involved in inflammation and the immune response.
E. Jimi, Nana Takakura, Fumitaka Hiura, I. Nakamura, S. Hirata-Tsuchiya   +4 more
semanticscholar   +1 more source

Raloxifene Has No Efficacy in Reducing the High Bone Turnover and the Risk of Spontaneous Vertebral Fractures after Denosumab Discontinuation

Case Reports in Rheumatology, 2018
At denosumab discontinuation, an antiresorptive agent is prescribed to reduce the high bone turnover, the rapid bone loss, and the risk of spontaneous vertebral fractures.
Elena Gonzalez-Rodriguez, Delphine Stoll, Olivier Lamy   +2 more
doaj   +1 more source

Successful management of colistin- and carbapenem-resistant -associated ecthyma gangrenosum in acute myeloid leukemia: A rare complication

SAGE Open Medical Case Reports, 2022
Pseudomonal ecthyma gangrenosum is a well-known condition in immunosuppressed patients. However, ecthyma gangrenosum associated with Klebsiella pneumoniae is a rare entity that requires early recognition and optimal antibiotic and surgical management. We
Aisha Jamal, Ali Saleem, Faiza Rezwan, Affaf Sheikh, Tahir Shamsi   +4 more
doaj   +1 more source

The role of GPCRs in bone diseases and dysfunctions

Bone Research, 2019
The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and functional diversity and mediates a myriad of biological processes upon activation by various extracellular signals.
Jian Luo, P. Sun, S. Siwko, Mingyao Liu, Jianru Xiao   +4 more
semanticscholar   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Relationship between dietary characteristics and heel quantitative ultrasound parameters in postmenopausal women from the OsteoLaus cohort

Scientific Reports
The role of dietary patterns in the development of osteoporosis is unclear. The heel quantitative ultrasound (QUS) is a potential alternative to Dual X-Ray Absorptiometry.
A. Lanyan, P. Marques-Vidal, A. Métrailler, E. Gonzalez Rodriguez, D. Hans, E. Shevroja, O. Lamy   +6 more
doaj   +1 more source

The doll therapy as a first line treatment for behavioral and psychologic symptoms of dementia in nursing homes residents: a randomized, controlled study

BMC Geriatrics, 2021
Background Patients living with dementia are severely affected by the development of behavioral and psychologic symptoms (BPSD) which represent a burden for patients and caregivers. The use of psychotropic drugs in the control of BPSD is widely diffused,
Francesca Santagata, Massimiliano Massaia, Patrizia D’Amelio   +2 more
doaj   +1 more source

Gadolinium tagged osteoprotegerin-mimicking peptide: a novel magnetic resonance imaging biospecific contrast agent for the inhibition of osteoclastogenesis and osteoclast activity [PDF]

, 2018
The control of osteoblast/osteoclast cross-talk is crucial in the bone remodelling process and provides a target mechanism in the development of drugs for bone metabolic diseases.
Busquets, Rosa, Cercignani, Mara, Dowell, Nicholas G, Mbundi, Lubinda, Meikle, Steve T, Santin, Matteo   +5 more
core   +6 more sources

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source