Results 11 to 20 of about 906,794 (309)

Thou Shalt not Fuse: Implant Survival Outcomes and Complications Following Arthroplasty in Hallux Rigidus [PDF]

Journal of Foot and Ankle Surgery (Asia Pacific), 2023
Aims and background: Hallux rigidus (HR) is a condition characterized by pain and loss of range of motion of the metatarsophalangeal joint (MTPJ) of the great toe caused by degenerative arthritis.
Freideriki Poutoglidou, Isabella Drummond, Joon Ha, Amit Patel, Francesc Malagelada, Lee Parker, Luckshmana Jeyaseelan   +6 more
doaj   +1 more source

CAISC: A software to integrate copy number variations and single nucleotide mutations for genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing

BMC Bioinformatics, 2022
Background Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study intratumor heterogeneity and detect clonal groups, a software that integrates these two ...
Jeerthi Kannan, Liza Mathews, Zhijie Wu, Neal S. Young, Shouguo Gao   +4 more
doaj   +1 more source

Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed

BMC Musculoskeletal Disorders, 2017
Background Many patients who undergo anterior cruciate ligament (ACL) reconstructive surgery develop post-traumatic osteoarthritis (PTOA). ACL reconstructive surgery may not fully restore pre-injury joint biomechanics, thereby resulting in further joint ...
B. J. Heard, J. E. Beveridge, M. Atarod, E. J. O’Brien, C. Rolian, C. B. Frank, D. A. Hart, N. G. Shrive   +7 more
doaj   +1 more source

An effective treatment in Erdheim Chester disease: vemurafenib: a case report

Journal of Medical Case Reports, 2023
Background Erdheim Chester disease (ECD) is a rare disease with multisystemic involvement in the group of non-langerhans cell histiocytosis. Although nearly 100 years have passed since its definition, the number of cases reported all over the world is ...
Ersin Bozan, Tahir Darçın, Samet Yaman, Tuğçe Nur Yiğenoğlu, Merih Kızıl Çakar, Mehmet Sinan Dal, Fevzi Altuntaş   +6 more
doaj   +1 more source

Third BNT162b2 mRNA SARS-CoV-2 Vaccine Dose Significantly Enhances Immunogenicity in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

Vaccines, 2023
COVID-19-related mortality among hematopoietic stem cell transplantation (HSCT) recipients in the pre-vaccine era ranged between 22 and 33%. The Pfizer/BioNTech BNT162b2 vaccine demonstrated significant immunogenicity and efficacy in the healthy ...
Israel Henig, Jonathan Isenberg, Dana Yehudai-Ofir, Ronit Leiba, Shimrit Ringelstein-Harlev, Ron Ram, Batia Avni, Odelia Amit, Sigal Grisariu, Tehila Azoulay, Ilana Slouzkey, Tsila Zuckerman   +11 more
doaj   +1 more source

The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis

Scientific Reports, 2021
The aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines.
Claudia Cristina Biguetti, Joel Ferreira Santiago Junior, Matthew William Fiedler, Mauro Toledo Marrelli, Marco Brotto   +4 more
doaj   +1 more source

The Influence of Supplemental Dietary Linoleic Acid on Skeletal Muscle Contractile Function in a Rodent Model of Barth Syndrome

Frontiers in Physiology, 2021
Barth syndrome is a rare and incurable X-linked (male-specific) genetic disease that affects the protein tafazzin (Taz). Taz is an important enzyme responsible for synthesizing biologically relevant cardiolipin (for heart and skeletal muscle, cardiolipin
Mario Elkes, Martin Andonovski, Daislyn Vidal, Madison Farago, Ryan Modafferi, Steven M. Claypool, Paul J. LeBlanc   +6 more
doaj   +1 more source

Cardiolipin content, linoleic acid composition, and tafazzin expression in response to skeletal muscle overload and unload stimuli

Scientific Reports, 2017
Cardiolipin (CL) is a unique mitochondrial phospholipid that, in skeletal muscle, is enriched with linoleic acid (18:2n6). Together, CL content and CL 18:2n6 composition are critical determinants of mitochondrial function. Skeletal muscle is comprised of
Val A. Fajardo, John S. Mikhaeil, Cameron F. Leveille, Caitlin Saint, Paul J. LeBlanc   +4 more
doaj   +1 more source

Multilevel instrumented posterolateral lumbar spine fusion with an allogeneic cellular bone graft

Journal of Orthopaedic Surgery and Research, 2019
Background Low back pain (LBP) is the leading cause of absence from work, disability, and impaired quality of life. Fusion surgery may be indicated when non-operative treatments have failed to provide relief.
John F. Hall, Julie B. McLean, Savannah M. Jones, Mark A. Moore, Michelle D. Nicholson, Kimberly A. Dorsch   +5 more
doaj   +1 more source

The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment

Arthritis Research & Therapy, 2020
Background Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes have been reported in OA synovium ...
Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith, Christopher B. Little   +5 more
doaj   +1 more source