Results 51 to 60 of about 1,205,322 (296)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function

Biomolecules, 2020
Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates ...
Azadeh Montaseri, Claudia Giampietri, Michela Rossi, Anna Riccioli, Andrea Del Fattore, Antonio Filippini   +5 more
doaj   +1 more source

Driving the Mineral out Faster: Simple Modifications of the Decalcification Technique [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Quicker decalcification is essential for faster diagnosis of hard tissue pathology. Heat and mechanical agitation are known to hasten decalcification. Aim: To compare the rate of decalcification, cellular and staining characteristics of
Supriya Nikita Kapila, Srikant Natarajan, Karen Boaz, Jay Ashokkumar Pandya, Shanmukha Raviteja Yinti   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Was dinosaurian physiology inherited by birds? [PDF]

, 2009
Archaeopteryx is the oldest and most primitive known bird (Avialae). It is believed that the growth and energetic physiology of basalmost birds such as Archaeopteryx were inherited in their entirety from non-avialan dinosaurs.
Erickson Gregory M., Norell, Mark A., Mark A Norell, Rauhut, Oliver W. M., Alan H. Turner, Mark A. Norell, Dongyu Hu, Turner Alan H., Oliver W M Rauhut, Gregory M Erickson, Zhonghe Zhou, Alan H Turner, Inouye, Brian D., Hu Dongyu, Brian D Inouye, Erickson, Gregory M., Hu, Dongyu, Norell Mark A., Inouye Brian D., Brian D. Inouye, Oliver W. M. Rauhut, Zhou Zhonghe, Rauhut Oliver W. M., Zhou, Zhonghe, Turner, Alan H., Gregory M. Erickson   +25 more
core   +2 more sources

Bone histology in a fossil elephant (Elephas maximus) from Pulau Bangka, Indonesia

, 2022
Analyses of Pleistocene fossil proboscideans have long been used as indirect evidence for climactic and environmental shifts in the Sunda shelf of Southeast Asia.
Basilia, Pauline, Nganvongpanit, Korakot, Puspaningrum, Mika R, van der Geer, Alexandra AE, Trihascaryo, Agus, Aswan, Louys, Julien, Miszkiewicz, Justyna J, Gilbert J, Price, Zaim, Jahdi, Rizal, Yan   +10 more
core   +1 more source

Comprehensive histological evaluation of bone implants [PDF]

Biomatter, 2014
To investigate and assess bone regeneration in sheep in combination with new implant materials classical histological staining methods as well as immunohistochemistry may provide additional information to standard radiographs or computer tomography. Available published data of bone defect regenerations in sheep often present none or sparely labeled ...
Rentsch, Claudia, Schneiders, Wolfgang, Manthey, Suzanne, Rentsch, Barbe, Rammelt, Stefan   +4 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Surface bone histology of the occipital bone in humans and chimpanzees [PDF]

The Anatomical Record Part B: The New Anatomist, 2005
AbstractHuman and chimpanzee occipital bones are thought to grow and develop in distinctly opposite bone remodeling patterns. Preliminary research examining growth‐remodeling fields (GRFs) from the surfaces of the occipital bone in modern humans and chimpanzee indicates this may not be entirely correct.
openaire   +2 more sources