Results 251 to 260 of about 374,545 (305)

Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis. [PDF]

open access: yesBone Res
Li L   +15 more
europepmc   +1 more source

Extracellular purines and bone homeostasis

Biochemical Pharmacology, 2021
Maintenance of a healthy skeleton is highly dependent on an intricate regulation of bone metabolism, as changes in the balance between bone formation and bone resorption leads to bone loss, bone fragility and ultimately bone fractures. During the last three decades it has become increasingly evident that physiological release of purines in the ...
Agrawal, Ankita, Jørgensen, Niklas R.
openaire   +3 more sources

Sodium homeostasis and bone

Current Opinion in Nephrology and Hypertension, 2014
Sodium balance is primarily regulated through the renin-angiotensin-aldosterone system. Extracellular fluid (ECF) sodium concentrations ([Na]) reflect the overall body sodium content, but are also influenced by the osmoregulatory system, which is regulated by the posterior pituitary hormone arginine vasopressin (AVP).
Mark J, Hannon, Joseph G, Verbalis
openaire   +2 more sources

Macrophages in Bone Homeostasis

Current Stem Cell Research & Therapy, 2019
Aberrant or prolonged immune responses has been proved to be involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to the various panel of stimuli, macrophages can be plastically classified into two major phenotypes: M1 and M2. M1 macrophages
Lingbo, Kong   +3 more
openaire   +2 more sources

Bone morphogenetic protein signaling in bone homeostasis

Bone, 2015
Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth factor-β (TGF-β) superfamily. They play multiple functions during development and tissue homeostasis, including regulation of the bone homeostasis. The BMP signaling pathway consists in a well-orchestrated manner of ligands, membrane receptors, co-receptors and ...
Sanchez Duffhues, G.   +3 more
openaire   +3 more sources

PPARγ in bone homeostasis

Trends in Endocrinology & Metabolism, 2010
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. Emerging evidence reveals that PPARγ is also a key modulator of skeletal remodeling.
openaire   +2 more sources

Sodium Homeostasis and Bone

The FASEB Journal, 2017
Growing evidence suggests that skeletal bone, which contains 30–40% of total body sodium in humans, may play a role in body sodium homeostasis. Sodium balance is primarily regulated through the renin‐angiotensin‐aldosterone system (RAAS). Extracellular fluid (ECF) sodium concentrations ([Na +
Joseph George Verbalis   +2 more
openaire   +1 more source

Epigenetic pathways regulating bone homeostasis

Bone, 2015
Epigenetic control of the genome involves a complex series of unique, physiologically responsive and integrated pathways, each with distinct mechanisms. Insight into epigenetic regulation has transformed understanding of inheritance, development and a broad spectrum of biological processes as well as advances in mechanistic and clinical ...
openaire   +2 more sources

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