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Macrophages in Bone Homeostasis
Current Stem Cell Research & Therapy, 2019Aberrant or prolonged immune responses has been proved to be involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to the various panel of stimuli, macrophages can be plastically classified into two major phenotypes: M1 and M2. M1 macrophages
Lingbo, Kong +3 more
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Energy homeostasis in the bone
Trends in Endocrinology and MetabolismThe bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases.
Xianghang Luo, Hai-Yan Zhou
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Regulation of Bone Homeostasis by Osteocytes
Ortopedia Traumatologia Rehabilitacja, 2015New data concerning the function of osteocytes as the central regulators of bone homeostasis are briefly outlined. It is established that osteocytes are the main target cells for parathormone. They are a rich source of sclerostin, the main inhibitor of osteoblast activity, and of the RANKL cytokine, the most important regulator of osteoclastogenesis ...
Grzegorz Szczęsny +4 more
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Skeletal interoception in bone homeostasis and pain
Cell Metabolism, 2022Accumulating evidence indicates that interoception maintains proper physiological status and orchestrates metabolic homeostasis by regulating feeding behaviors, glucose balance, and lipid metabolism. Continuous skeletal remodeling consumes a tremendous amount of energy to provide skeletal scaffolding, support muscle movement, store vital minerals, and ...
Xiao, Lv, Feng, Gao, Xu, Cao
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Trends in Endocrinology & Metabolism, 2010
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. Emerging evidence reveals that PPARγ is also a key modulator of skeletal remodeling.
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The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. Emerging evidence reveals that PPARγ is also a key modulator of skeletal remodeling.
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The role of the intestine in bone homeostasis
European Journal of Gastroenterology & Hepatology, 2003The intestine is critical for calcium absorption and skeletal mineralization. Nutritional factors affect the dietary intake of calcium and its bioavailability in the intestine. Individuals differ considerably in their ability to absorb calcium but the reasons for this physiological variation are not fully understood although much is now known about the
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The FASEB Journal, 2017
Growing evidence suggests that skeletal bone, which contains 30–40% of total body sodium in humans, may play a role in body sodium homeostasis. Sodium balance is primarily regulated through the renin‐angiotensin‐aldosterone system (RAAS). Extracellular fluid (ECF) sodium concentrations ([Na +
Joseph George Verbalis +2 more
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Growing evidence suggests that skeletal bone, which contains 30–40% of total body sodium in humans, may play a role in body sodium homeostasis. Sodium balance is primarily regulated through the renin‐angiotensin‐aldosterone system (RAAS). Extracellular fluid (ECF) sodium concentrations ([Na +
Joseph George Verbalis +2 more
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Semaphorins in Bone Homeostasis
2015Intercellular communication between cells within bone is essential for the regulation of bone homeostasis. Growing evidence reveals that semaphorins have crucial roles in this process, including osteoclastic bone resorption and osteoblastic bone formation.
Mikihito Hayashi +2 more
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Latest perspectives on macrophages in bone homeostasis
Pflügers Archiv - European Journal of Physiology, 2017Knowledge about macrophages residing in the bone, also known as osteal macrophages or osteomacs, is still limited. A hallmark of this peculiar myeloid population is the expression of macrophage markers distinct from the markers found on osteoclast surface.
Aline, Bozec, Didier, Soulat
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Inflammation-Associated Changes in Bone Homeostasis
Inflammation & Allergy-Drug Targets, 2012Bone is a dynamic tissue undergoing constant remodelling and repair. Its homeostasis is regulated by a coordinated process executed by bone forming and bone resorbing cells. Apart from being a major component of the locomotive system, bone provides protection for internal organs and represents a main mineral storage.
Carina, Scholtysek +2 more
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