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[Bone remodeling: a role in bone homeostasis].
Nihon rinsho. Japanese journal of clinical medicine, 2009Bone remodeling is composed of bone formation and resorption. Structural integrity and strength of bone is maintained by the balance between bone formation and resorption.
Itsuro, Endo, Toshio, Matsumoto
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Semaphorins in bone development, homeostasis, and disease
Seminars in Cell & Developmental Biology, 2013Semaphorins were originally identified as axon guidance cues in the development of the nervous system. In recent years, numerous studies have determined that they are also involved in organogenesis, vascularization/angiogenesis, oncogenesis, and immune responses.
Sujin, Kang, Atsushi, Kumanogoh
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Epigenetic pathways regulating bone homeostasis
Bone, 2015Epigenetic control of the genome involves a complex series of unique, physiologically responsive and integrated pathways, each with distinct mechanisms. Insight into epigenetic regulation has transformed understanding of inheritance, development and a broad spectrum of biological processes as well as advances in mechanistic and clinical ...
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Neurotoxicology, 1993
The principal repository of calcium is bone. Calcium enters bone largely via the trabeculae, with the rate of calcium clearance by bone approximating 50 percent. Calcium enters bone as an ion in solution, but undergoes a phase change to a solid as soon as in contact with the bone surfaces.
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The principal repository of calcium is bone. Calcium enters bone largely via the trabeculae, with the rate of calcium clearance by bone approximating 50 percent. Calcium enters bone as an ion in solution, but undergoes a phase change to a solid as soon as in contact with the bone surfaces.
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[Regulation of bone homeostasis by bone cells].
Clinical calcium, 2013Bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic bone resorption both of which mainly occur at the bone surface. This restructuring process called "bone remodeling" is important not only for normal bone mass and strength, but also for mineral homeostasis.
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Role of RANKL Signaling in Bone Homeostasis
PhysiologyRANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that unveiled the paramount role of this signaling pathway. We focus on the RANKL cytokine, whose alterations are responsible for rare and common bone diseases.
Sobacchi C. +3 more
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Bone mass homeostasis and bisphosphonate action
Bone, 1997The evidence supporting the concept of bone mass homeostasis controlled by mechanical loads is summarized. The well-known adaptation of bone structure to mechanical loads can only be achieved if an increase in load stimulates bone formation and a decrease stimulates bone resorption.
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Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review
Journal of Functional Biomaterials, 2023Wang Junwu +2 more
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