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Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis. [PDF]
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Extracellular purines and bone homeostasis
Biochemical Pharmacology, 2021Maintenance of a healthy skeleton is highly dependent on an intricate regulation of bone metabolism, as changes in the balance between bone formation and bone resorption leads to bone loss, bone fragility and ultimately bone fractures. During the last three decades it has become increasingly evident that physiological release of purines in the ...
Agrawal, Ankita, Jørgensen, Niklas R.
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Current Opinion in Nephrology and Hypertension, 2014
Sodium balance is primarily regulated through the renin-angiotensin-aldosterone system. Extracellular fluid (ECF) sodium concentrations ([Na]) reflect the overall body sodium content, but are also influenced by the osmoregulatory system, which is regulated by the posterior pituitary hormone arginine vasopressin (AVP).
Mark J, Hannon, Joseph G, Verbalis
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Sodium balance is primarily regulated through the renin-angiotensin-aldosterone system. Extracellular fluid (ECF) sodium concentrations ([Na]) reflect the overall body sodium content, but are also influenced by the osmoregulatory system, which is regulated by the posterior pituitary hormone arginine vasopressin (AVP).
Mark J, Hannon, Joseph G, Verbalis
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Macrophages in Bone Homeostasis
Current Stem Cell Research & Therapy, 2019Aberrant or prolonged immune responses has been proved to be involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to the various panel of stimuli, macrophages can be plastically classified into two major phenotypes: M1 and M2. M1 macrophages
Lingbo, Kong +3 more
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Bone morphogenetic protein signaling in bone homeostasis
Bone, 2015Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth factor-β (TGF-β) superfamily. They play multiple functions during development and tissue homeostasis, including regulation of the bone homeostasis. The BMP signaling pathway consists in a well-orchestrated manner of ligands, membrane receptors, co-receptors and ...
Sanchez Duffhues, G. +3 more
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Trends in Endocrinology & Metabolism, 2010
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. Emerging evidence reveals that PPARγ is also a key modulator of skeletal remodeling.
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The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. Emerging evidence reveals that PPARγ is also a key modulator of skeletal remodeling.
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The FASEB Journal, 2017
Growing evidence suggests that skeletal bone, which contains 30–40% of total body sodium in humans, may play a role in body sodium homeostasis. Sodium balance is primarily regulated through the renin‐angiotensin‐aldosterone system (RAAS). Extracellular fluid (ECF) sodium concentrations ([Na +
Joseph George Verbalis +2 more
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Growing evidence suggests that skeletal bone, which contains 30–40% of total body sodium in humans, may play a role in body sodium homeostasis. Sodium balance is primarily regulated through the renin‐angiotensin‐aldosterone system (RAAS). Extracellular fluid (ECF) sodium concentrations ([Na +
Joseph George Verbalis +2 more
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Epigenetic pathways regulating bone homeostasis
Bone, 2015Epigenetic control of the genome involves a complex series of unique, physiologically responsive and integrated pathways, each with distinct mechanisms. Insight into epigenetic regulation has transformed understanding of inheritance, development and a broad spectrum of biological processes as well as advances in mechanistic and clinical ...
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Energy homeostasis in the bone
Trends in Endocrinology & MetabolismThe bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases.
Min, Zhou +4 more
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Inflammation-Associated Changes in Bone Homeostasis
Inflammation & Allergy-Drug Targets, 2012Bone is a dynamic tissue undergoing constant remodelling and repair. Its homeostasis is regulated by a coordinated process executed by bone forming and bone resorbing cells. Apart from being a major component of the locomotive system, bone provides protection for internal organs and represents a main mineral storage.
Carina, Scholtysek +2 more
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