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Energy homeostasis in the bone
Trends in Endocrinology & MetabolismThe bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases.
Min, Zhou +4 more
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Inflammation-Associated Changes in Bone Homeostasis
Inflammation & Allergy-Drug Targets, 2012Bone is a dynamic tissue undergoing constant remodelling and repair. Its homeostasis is regulated by a coordinated process executed by bone forming and bone resorbing cells. Apart from being a major component of the locomotive system, bone provides protection for internal organs and represents a main mineral storage.
Carina, Scholtysek +2 more
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Semaphorins in Bone Homeostasis
2015Intercellular communication between cells within bone is essential for the regulation of bone homeostasis. Growing evidence reveals that semaphorins have crucial roles in this process, including osteoclastic bone resorption and osteoblastic bone formation.
Mikihito Hayashi +2 more
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Regulation of Bone Homeostasis by Osteocytes
Ortopedia Traumatologia Rehabilitacja, 2015New data concerning the function of osteocytes as the central regulators of bone homeostasis are briefly outlined. It is established that osteocytes are the main target cells for parathormone. They are a rich source of sclerostin, the main inhibitor of osteoblast activity, and of the RANKL cytokine, the most important regulator of osteoclastogenesis ...
Grzegorz Szczęsny +4 more
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Bone mass homeostasis and bisphosphonate action
Bone, 1997The evidence supporting the concept of bone mass homeostasis controlled by mechanical loads is summarized. The well-known adaptation of bone structure to mechanical loads can only be achieved if an increase in load stimulates bone formation and a decrease stimulates bone resorption.
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Drugs Affecting Bone Mineral Homeostasis
2021Bone mineral homeostasis is a key function of the human endocrine system. This homeostasis revolves around multiple arches, chiefly involving calcium, vitamin D, parathyroid hormone, calcitonin, estrogen, glucocorticoids, and others. While the conventional drugs used for management of bone mineral metabolic disturbances have always been calcium ...
Sushil Kiran Kunder, Avinash Arivazhahan
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Cellular Contributors to Bone Homeostasis
2020Bone is a complex and dynamic tissue that, in addition to its biomechanical properties, harbors stem cells and precursor cells of the hematopoietic and immune system. The skeleton undergoes continuous remodeling processes to maintain proper bone homeostasis.
Martina Rauner +4 more
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Neurotoxicology, 1993
The principal repository of calcium is bone. Calcium enters bone largely via the trabeculae, with the rate of calcium clearance by bone approximating 50 percent. Calcium enters bone as an ion in solution, but undergoes a phase change to a solid as soon as in contact with the bone surfaces.
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The principal repository of calcium is bone. Calcium enters bone largely via the trabeculae, with the rate of calcium clearance by bone approximating 50 percent. Calcium enters bone as an ion in solution, but undergoes a phase change to a solid as soon as in contact with the bone surfaces.
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[Bone remodeling: a role in bone homeostasis].
Nihon rinsho. Japanese journal of clinical medicine, 2009Bone remodeling is composed of bone formation and resorption. Structural integrity and strength of bone is maintained by the balance between bone formation and resorption.
Itsuro, Endo, Toshio, Matsumoto
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Calcium Homeostasis and Bone Metabolism
Hospital Practice, 1970Parathyroid hormone and thyrocalcitonin act in opposite directions to provide the key elements in a reciprocal control system that guards calcium's availability. The former (with vitamin D) acts to stimulate bone resorption, the latter (with phosphate) to inhibit it.
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