Results 91 to 100 of about 2,974,131 (410)

Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease [PDF]

, 2004
Background— Cell therapy with bone marrow–derived stem/progenitor cells is a novel option for improving neovascularization and cardiac function in ischemic heart disease.
Aicher, A, Assmus, B, Dimmeler, S, Heeschen, C, Honold, J, Lehmann, R, Martin, H, Walter, DH, Zeiher, AM   +8 more
core   +1 more source

Distinct bone marrow blood vessels differentially regulate hematopoiesis

Nature, 2016
Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance.
T. Itkin, S. Gur-Cohen, J. Spencer, A. Schajnovitz, Saravana K. Ramasamy, Anjali P. Kusumbe, Guy Ledergor, Yookyung Jung, I. Milo, Michael G. Poulos, A. Kalinkovich, A. Ludin, O. Kollet, G. Shakhar, J. Butler, S. Rafii, R. Adams, D. Scadden, Charles P. Lin, T. Lapidot   +19 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

P1372: REAL-WORLD RETROSPECTIVE ANALYSIS OF INFECTIOUS COMPLICATIONS AFTER RUXOLITNIB USE IN ACUTE AND CHRONIC GRAFT-VERSUS-HOST DISEASE

HemaSphere, 2022
C. Sol Reis, D. Duarte, I. Brito, P. Silva Coelho, L. Leite, R. Branca, S. Roncon, C. Pinho Vaz, A. Campos   +8 more
doaj   +1 more source

Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. [PDF]

, 1987
The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b ...
Hansteen, GA, Lieberman, M, McCune, JM, Scott, ML, Weissman, IL, White, JH   +5 more
core  

Quantitative MRI and spectroscopy of bone marrow

Journal of Magnetic Resonance Imaging, 2017
Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells.
D. Karampinos, S. Ruschke, M. Dieckmeyer, M. Diefenbach, Daniela Franz, A. Gersing, R. Krug, T. Baum   +7 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow [PDF]

, 2016
Bone metastasis is a leading cause of morbidity and mortality in prostate cancer (PCa). While cancer stem-like cells have been implicated as a cell of origin for PCa metastases, the pathways which enable metastatic development at distal sites remain ...
Albert Rizvanov, Andreas Hedblom, Athanasios Simoulis, Brian Robinson, Cinzia Allegrucci, Collins, David M. Heery, Jenny L. Persson, Johan Malm, Julius Semenas, Magni, Marcinkiewicz, Nigel P. Mongan, Norman J. Maitland, Pettaway, Regina Miftakhova, Sophos, Wegiel   +17 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source