Results 81 to 90 of about 1,199,930 (384)

Differentiation of metastatic lesions to the bones and multiple myeloma – a case study

Journal of Education, Health and Sport, 2020
Bones are one of the most common locations for cancer metastasis. Foci, which are in the most cases osteolytic, are located in the spine, ribs, pelvis, long bones.
Olaf Pachciński, Paulina Przywara, Adam Raabe, Bartłomiej Zaremba, Aneta Szudy-Szczyrek, Marek Hus   +5 more
doaj   +1 more source

Rescue of myeloid lineage-committed preprogenitor cells from cytomegalovirus-infected bone marrow stroma [PDF]

, 1991
The effect of murine cytomegalovirus on myelopoiesis was studied in long-term bone marrow culture to find an in vitro correlate for the lethal virus interference with bone marrow reconstitution (W. Mutter, M. J. Reddehase, F. W. Busch, H.-J. Bühring, and
Busch, Friedrich W., Koszinowski, Ulrich H., Mutter, Wolfgang, Reddehase, Matthias J.   +3 more
core   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Blastic plasmacytoid dendritic cell neoplasia - a rare type of acute leukemia

Romanian Journal of Laboratory Medicine, 2014
Neoplasmul cu celule dendritice plasmocitoide blastice (NCDPB), clasificat recent în grupul leucemiilor acute mieloide este o boală hematologică malignă rară cu evoluţie clinică extrem de agresivă.
Köpeczi Judit Beáta, Benedek Erzsébet, Kakucs Enikő, Tunyogi Aliz, Istrati Monica, Benedek Istvan   +5 more
doaj   +1 more source

A distinct molecular mutational profile and its clinical impact in essential thrombocythemia and primary myelofibrosis patients

BMC Cancer, 2020
Background Classical MPNs including ET and PMF have a chronic course and potential for leukaemic transformation. Timely diagnosis is obligatory to ensure appropriate management and positive outcomes.
Uzma Zaidi, Gul Sufaida, Munazza Rashid, Bushra Kaleem, Sidra Maqsood, Samina Naz Mukry, Rifat Zubair Ahmed Khan, Saima Munzir, Munira Borhany, Tahir Sultan Shamsi   +9 more
doaj   +1 more source

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. [PDF]

, 2018
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes.
Aftab, Blake T, Ferguson, Ian D, Hann, Byron C, Lam, Christine, Lin, Yu-Hsiu T, Liu, Hui, Liu, Jun O, Mariano, Margarette C, Mitsiades, Constantine S, Murnane, Megan, Smith, Geoffrey A, Taunton, Jack, Wiita, Arun P, Wong, Sandy W   +13 more
core   +2 more sources

Is the immediate effect of marathon running on novice runners' knee joints sustained within 6 months after the run? A follow-up 3.0 T MRI study. [PDF]

, 2020
OBJECTIVE: To evaluate changes in the knee joints of asymptomatic first-time marathon runners, using 3.0 T MRI, 6 months after finishing marathon training and run.
D'Silva, A, Di Laura, A, Fotiadou, A, Hart, AJ, Henckel, J, Hirschmann, AC, Horga, LM, Moon, JC, Sharma, S, Torlasco, C   +9 more
core   +2 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Modeling the Multiple Myeloma Vicious Cycle: Signaling Across the Bone Marrow Microenvironment [PDF]

arXiv, 2015
Multiple myeloma is a plasma cell cancer that leads to a dysregulated bone remodeling process. We present a partial differential equation model describing the dynamics of bone remodeling with the presence of myeloma tumor cells. The model explicitly takes into account the roles of osteoclasts, osteoblasts, precursor cells, stromal cells, osteocytes ...
arxiv  

Collagenous bone matrix-induced endochondral ossification hemopoiesis. [PDF]

, 1976
Transplantation of collagenous matrix from the rat diaphyseal bone to subcutaneous sites resulted in new bone formation by an endochondral sequence. Functional bone marrow develops within the newly formed ossicle.
Anderson, WA, Reddi, AH
core