Results 191 to 200 of about 630,798 (317)

Evaluation of two semi-supervised learning methods and their combination for automatic classification of bone marrow cells. [PDF]

Sci Rep, 2022
Nakamura I, Ida H, Yabuta M, Kashiwa W, Tsukamoto M, Sato S, Ota S, Kobayashi N, Masauzi H, Okada K, Kaga S, Miwa K, Kanai H, Masauzi N.   +13 more
europepmc   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

<i>Carica Papaya</i> Linn. Leaf Extracts Induced the Proliferation of Mice's Peritoneal Macrophages and Bone Marrow Cells, Along with Cytokine Modulation in Cell Culture. [PDF]

J Exp Pharmacol
Nikiema WA, Sanou GS, Da AZ, Sore H, Ouedraogo BHA, Sondo KA, Kabore RAF, Semdé R, Ouedraogo M.   +8 more
europepmc   +1 more source

Single-Cell RNA-Seq of Bone Marrow Cells in Aplastic Anemia. [PDF]

Front Genet, 2021
Tonglin H, Yanna Z, Xiaoling Y, Ruilan G, Liming Y.   +4 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Protocol for the generation and assessment of functional macrophages from mouse bone marrow cells. [PDF]

STAR Protoc
Scafidi A, Lind-Holm Mogensen F, Michelucci A.   +2 more
europepmc   +1 more source

The effect of low doses of chlorpyrifos on blood and bone marrow cells in Wistar rats. [PDF]

Arh Hig Rada Toksikol, 2022
Kašuba V, Micek V, Milić M, Želježić D, Katić A.   +4 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

TLR7/8 ligands R848 and imiquimod induce differentiation of bone marrow cells from patients with myelodysplastic syndrome towards mature neutrophils. [PDF]

Sci Rep
Villamón E, Guerrero P, Gil ML, Martín I, Amat P, Gozalbo D, Yáñez A.   +6 more
europepmc   +1 more source

A Water Extract from Chlorella sorokiniana Cell Walls Stimulates Growth of Bone Marrow Cells and Splenocytes. [PDF]

Nutrients, 2022
Ishiguro S, Roth M, Welti R, Loyd M, Thakkar R, Phillips M, Robben N, Upreti D, Nakashima A, Suzuki K, Comer J, Tamura M.   +11 more
europepmc   +1 more source