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Stem cell differentiation in the bone-marrow

Immunology Today, 1981
Even in the absence of antigenic challenge, the adult immune system is in a state of constant flux and each day receives large numbers of newly formed lymphocytes. The bone-marrow is vital to this continuous renewal, both in its regulation and because it is the direct source of B cells in normal animals and the indirect source of T cells, which are ...
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VERSATILE STEM CELLS IN BONE MARROW

The Lancet, 1982
The question of whether there is a single pluripotent haemopoietic stem cell or a variety of stem cells each with a capacity for self-replication is still unresolved. Evidence from radiation-chimaeras and from patients with marrow grafts indicates that haemopoietic stem cells are not a homogeneous population.
J F, Loutit   +3 more
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Ultrastructure of reticulum cells in the bone marrow

Cells Tissues Organs, 1978
In this study the attempt was made to classify the reticulum cells of the bone marrow on the basis of electron-microscopic findings. The basis of the differentiation was the ability of the cells to phagocytize substances or not. For two cell types the intracytoplasmic filaments were used as distinctive marks.
A, Biermann, D, Graf von Keyserlingk
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Bone Marrow in Hairy Cell Leukemia

Hematology/Oncology Clinics of North America, 1988
HCL is a well-recognized entity among the lymphoproliferative disorders. With better appreciation of the wide variability in its clinical and hematologic manifestations, some authors have proposed several subtypes of HCL such as leukopenic and nonleukopenic subtypes and subtypes with and without massive splenomegaly.
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Bone Marrow and B Cell Differentiation

1982
Recent progress in the B lymphocyte field has been rapid. However, the revelations of immunoglobulin gene expression, genesis of antibody diversity and hybridoma technology all serve to highlight outstanding questions conerning the in vivo organization of B lymphocytes and their progenitors.
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The architecture of bone marrow cell populations

The International Journal of Cell Cloning, 1990
Marrow is a loosely bound tissue in which hemopoiesis has frequently been considered to be randomly distributed. The case is presented, however, for an organized and structured marrow in which close relationships exist between hemopoietic tissue and a regulatory microenvironment.
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Counting Cells in Human Bone Marrow

American Journal of Clinical Pathology, 1974
A method for estimation of human bone marrow cellularity is described. After bone marrow puncture, the aspirate is sieved, and the retained particles flushed with cold plasma. They are then aspirated in a glass capillary tube of known volume, and after centrifugation the packed material is measured.
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Stem cells as bone marrow residents

Biology Bulletin, 2011
In addition to being a source of hematopoietic and mesenchymal stromal cells, bone marrow is known to be the source of stem cell populations, which express pluripotential markers and are capable of differentiating into cells of three blastophyllums (ectoderm, mesoderm, and endoderm).
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Bone marrow cell separation studies

Experimental Cell Research, 1960
Abstract Differential gradient centrifugation of bone marrow cell suspensions in bovine serum albumin produced layers of mixed cell types. Each layer was capable isologously of promoting survival of heavily irradiated (C57BL × 101)F 1 mice; none was more effective than fresh whole bone marrow.
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The Radiosensitivity of Rat Bone-marrow Cells

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1970
SummaryThe radiosensitivity of rat bone-marrow cells was determined by the spleen-colony technique. When the marrow cells were irradiated in vivo, the D0 was 97 rads, and the extrapolation number was 5·2. Similar results were obtained after in vitro irradiation: D0 = 94 rads, and extrapolation number = 4·1.
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