Probing the interaction forces of prostate cancer cells with collagen I and bone marrow derived stem cells on the single cell level. [PDF]
Adhesion of metastasizing prostate carcinoma cells was quantified for two carcinoma model cell lines LNCaP (lymph node-specific) and PC3 (bone marrow-specific).
Benoit, Martin+7 more
core +3 more sources
Clonal Dominance and Transplantation Dynamics in Hematopoietic Stem Cell Compartments [PDF]
Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments.
arxiv +1 more source
Lifetime of plasma cells in the bone marrow [PDF]
Immune protection is based on long-lived memory cells and effector cells, which are either cytotoxic or secrete antibodies. The lifespan of these effector cells has not so far been determined. Here we show that antibody-secreting plasma cells from bone marrow are as long-lived as memory B cells.
Rudolf A. Manz+2 more
openaire +2 more sources
Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients [PDF]
Objective: The effect of donor bone marrow was evaluated for its potentially favorable effect in the authors' simultaneous pancreas/kidney transplant program.
Abdul S. Rao+35 more
core +2 more sources
BackgroundIn recent years, chimeric antigen receptor (CAR)-T cell therapy has achieved tremendous efficacy in relapsed/refractory multiple myeloma (R/R MM).
Lingling Yin+54 more
doaj +1 more source
The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Background Lenalidomide improves erythropoiesis in patients with low/intermediate-1 risk myelodysplastic syndrome and interstitial deletion of the long arm of chromosome 5 [del(5q)].
Maria Ximeri+15 more
doaj +1 more source
A Fully Unsupervised Instance Segmentation Technique for White Blood Cell Images [PDF]
White blood cells, also known as leukocytes are group of heterogeneously nucleated cells which act as salient immune system cells. These are originated in the bone marrow and are found in blood, plasma, and lymph tissues. Leukocytes kill the bacteria, virus and other kind of pathogens which invade human body through phagocytosis that in turn results ...
arxiv
Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host [PDF]
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the ...
Busch, Friedrich W.+4 more
core +2 more sources