Results 31 to 40 of about 630,798 (317)

A T Cell View of the Bone Marrow [PDF]

Frontiers in Immunology, 2016
The majority of T cells present in the bone marrow (BM) represent an activated/memory phenotype and most of these, if not all, are circulating T cells. Their lodging in the BM keeps them activated, turning the BM microenvironment into a "memory reservoir." This article will focus on how T cell activation in the BM results in both direct and indirect ...
Bonomo, Adriana, Monteiro, Ana Carolina, Gonçalves-Silva, Triciana, Cordeiro-Spinetti, Eric, Galvani, Rômulo Gonçalves, Balduino, Alex   +5 more
openaire   +2 more sources

Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear-cytoplasmic labeling. [PDF]

PLoS ONE, 2017
Bone marrow is a vital tissue that produces the majority of erythrocytes, thrombocytes, and immune cells. Bone marrow transplantation (BMT) has been widely performed in patients with blood disorders and cancers.
Soyeon Ahn, Kibaek Choe, Seunghun Lee, Kangsan Kim, Eunjoo Song, Howon Seo, Injune Kim, Pilhan Kim   +7 more
doaj   +1 more source

GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells

Haematologica, 2014
The bone marrow microenvironment comprises multiple cell niches derived from bone marrow mesenchymal stem cells. However, the molecular mechanism of bone marrow mesenchymal stem cell differentiation is poorly understood. The transcription factor GATA2 is
Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae   +12 more
doaj   +1 more source

Absorption Microspectroscopy of Bone Marrow Cells [PDF]

Blood, 1955
Abstract Using a microspectrographic technic, reflecting optics and narrow bands of the continuum (5500, 4150 and 2650 Å), the author has obtained pictures of human and rat bone marrow cells in unfixed dry smears as well as in suspensions in vivo; erythroblasts showed different absorption patterns.
openaire   +2 more sources

Nutritional status indices on the prognosis of patients with relapsed and refractory multiple myeloma treated with CAR-T cell immunotherapy

Frontiers in Nutrition
Background aimsChimeric antigen receptor (CAR) T-cell therapy shows remarkable efficacy against relapsed/refractory multiple myeloma (R/R MM). Nutritional status, assessed by objective indices like the Controlling Nutritional Status (CONUT) and ...
Peng Xu, Peng Xu, Peng Xu, Yang Liu, Yang Liu, Yang Liu, Yawen Wang, Yawen Wang, Yawen Wang, Qiwen Feng, Qiwen Feng, Qiwen Feng, Huanxin Zhang, Huanxin Zhang, Huanxin Zhang, Hai Cheng, Hai Cheng, Hai Cheng, Kunming Qi, Kunming Qi, Kunming Qi, Kailin Xu, Kailin Xu, Kailin Xu, Zhenyu Li, Zhenyu Li, Zhenyu Li   +26 more
doaj   +1 more source

Angiogenesis Induced by the Implantation of Self-Bone Marrow Cells: A New Material for Therapeutic Angiogenesis

Cell Transplantation, 2000
Bone marrow contains various primitive cells that are thought to secrete several angiogenic growth factors and may also differentiate into endothelial cells. The present study was conducted to investigate the possibility that bone marrow cells could be a
Kimikazu Hamano M.D., Tao-Sheng Li, Toshiro Kobayashi, Sei Kobayashi, Masunori Matsuzaki, Kensuke Esato   +5 more
doaj   +1 more source

Karyotype of cryopreserved bone marrow cells [PDF]

Brazilian Journal of Medical and Biological Research, 2003
The analysis of chromosomal abnormalities is important for the study of hematological neoplastic disorders since it facilitates classification of the disease. The ability to perform chromosome analysis of cryopreserved malignant marrow or peripheral blast cells is important for retrospective studies.
Chauffaille, Maria de Lourdes Lopes Ferrari UNIFESP, Pinheiro, Ronald Feitosa UNIFESP, Stefano, Jose Tadeu UNIFESP, Kerbauy, José UNIFESP   +3 more
openaire   +5 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Construction and validation of a nutritional status (CONUT)-based nomogram for predicting prolonged hematological toxicity in relapsed/refractory multiple myeloma after CAR-T cell therapy

Frontiers in Nutrition
Background aimChimeric antigen receptor (CAR)-T cell therapy is highly effective for relapsed/refractory multiple myeloma (R/R MM). Prolonged hematological toxicity (PHT) is a significant adverse event that adversely affects patient outcomes; however ...
Peng Xu, Peng Xu, Peng Xu, Xin-Ying Duan, Xin-Ying Duan, Xin-Ying Duan, Qi-Wen Feng, Qi-Wen Feng, Qi-Wen Feng, Ya-Wen Wang, Ya-Wen Wang, Ya-Wen Wang, Yang Liu, Yang Liu, Yang Liu, Huan-Xin Zhang, Huan-Xin Zhang, Huan-Xin Zhang, Kun-Ming Qi, Kun-Ming Qi, Kun-Ming Qi, Zhen-Yu Li, Zhen-Yu Li, Zhen-Yu Li, Qing-Yun Wu, Qing-Yun Wu, Qing-Yun Wu   +26 more
doaj   +1 more source

Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]

, 2001
Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Thalmeier, Karin, Moosmann, Sabine, Wiest, Irmgard, Huss, Ralf, Meissner, Petra, Sagebiel, Sabine   +5 more
core   +1 more source