Results 61 to 70 of about 789,940 (327)

The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

BMC Cancer, 2021
Background Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG). Mesenchymal stromal cells (MSCs)
Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu, He Huang   +9 more
doaj   +1 more source

A Semi-parametric Promotion Time Cure Model with Support Vector Machine [PDF]

arXiv, 2023
The promotion time cure rate model (PCM) is an extensively studied model for the analysis of time-to-event data in the presence of a cured subgroup. There are several strategies proposed in the literature to model the latency part of PCM. However, there aren't many strategies proposed to investigate the effects of covariates on the incidence part of ...
arxiv  

Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation.

New England Journal of Medicine, 1994
BACKGROUND Lymphoma associated with Epstein-Barr virus (EBV) is a complication of bone marrow transplantation that responds poorly to standard forms of therapy. The lymphoma is usually of donor origin.
E. Papadopoulos, Marc P. Ladanyi, D. Emanuel, S. Mackinnon, F. Boulad, M. Carabasi, H. Castro-Malaspina, B. Childs, A. Gillio, T. Small, J. Young, N. Kernan, R. O'reilly   +12 more
semanticscholar   +1 more source

Leukemia with Plasma Cells — Case Report

Journal of Interdisciplinary Medicine, 2017
Plasma cell leukemia (PCL) is one of the most aggressive monoclonal gammopathies, being characterized by the presence of more than 20% of plasma cells in the peripheral blood and an absolute number of these cells of more than 2×109, with different ...
Benedek István, Benedek István, Köpeczi Judit Beáta, Kéri Johanna Sándor, Pakucs Annamária, Jakab Szende, Lázár Erzsébet   +6 more
doaj   +1 more source

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin.

Blood, 1996
Idiopathic pneumonia syndrome (IPS) refers to diffuse, non-infectious pneumonia that occurs after allogeneic bone marrow transplantation (BMT). We have developed a model of IPS using a well-characterized murine BMT system (B10.BR-->CBA) in which lung ...
K. Cooke, L. Kobzik, T. Martin, J. Brewer, J. Delmonte, J. M. Crawford, J. Ferrara   +6 more
semanticscholar   +1 more source

Dengue virus infection in hematopoietic stem cell transplant recipients: A case series and comparative literature review from dengue endemic region

SAGE Open Medical Case Reports
This case series describes the wide spectrum of clinical presentation, laboratory findings, and morbidity/mortality associated with dengue fever in hematopoietic stem cell transplant recipients, treated in a dengue endemic region.
Waseem Shahani, Faiqa Fayyaz, Shafaq Abdul Samad, Muhammad Nizamuddin, Madiha Abid, Aisha Jamal, Zainab Ghayas, Ayesha Rafiq, Abdul Hayee, Dilnasheen Safdar, Tasleem Farzana, Uzma Zaidi   +11 more
doaj   +1 more source

Watch and Wait – Actualities in the Treatment of Chronic Lymphocytic Leukemia

Journal of Interdisciplinary Medicine, 2017
In Western countries, chronic lymphocytic leukemia (CLL) is one of the most diagnosed leukemia types among elderly patients. CLL is described as an indolent lymphoproliferative disorder, characterized by the presence of a high number of small, mature B ...
Bíró Szilárd, Benedek István, Bzduch Árpád, Sándor-Kéri Johanna, Lázár Erzsébet, Benedek István   +5 more
doaj   +1 more source

Metabolic reprogramming in macrophage responses

Biomarker Research, 2021
Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai   +9 more
doaj   +1 more source

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

Journal of Experimental Medicine, 2012
GVHD is associated with significant shifts in the composition of the intestinal microbiota in human and mouse models; manipulating the microbiota can alter the severity of GVHD in mice.
R. Jenq, C. Ubeda, Y. Taur, C. C. Menezes, R. Khanin, J. Dudakov, Chen Liu, Mallory L. West, Natalie V. Singer, Michele J. Equinda, Asia Gobourne, Lauren Lipuma, L. Young, Odette M. Smith, Arnab Ghosh, A. Hanash, J. Goldberg, K. Aoyama, B. Blazar, E. Pamer, Marcel R.M. van den Brink   +20 more
semanticscholar   +1 more source

Immune Reconstitution-Based Score for Risk Stratification of Chronic Graft-Versus-Host Disease Patients

Frontiers in Oncology, 2021
IntroductionAllogeneic stem cell transplantation survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality.
Fabio Serpenti, Francesca Lorentino, Francesca Lorentino, Sarah Marktel, Raffaella Milani, Carlo Messina, Raffaella Greco, Stefania Girlanda, Daniela Clerici, Fabio Giglio, Carmine Liberatore, Francesca Farina, Sara Mastaglio, Simona Piemontese, Elena Guggiari, Francesca Lunghi, Magda Marcatti, Matteo G. Carrabba, Massimo Bernardi, Chiara Bonini, Chiara Bonini, Andrea Assanelli, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Fabio Ciceri, Maria Teresa Lupo-Stanghellini   +26 more
doaj   +1 more source