Results 71 to 80 of about 483,425 (231)
Stem Cell Research & Therapy, 2023 Background In vertebrates, hematopoietic stem and progenitor cells (HSPCs) emerge from hemogenic endothelium in the floor of the dorsal aorta and subsequently migrate to secondary niches where they expand and differentiate into committed lineages.
Honghu Li +9 more
doaj +1 more source
Estimation in a semiparametric modulated renewal process [PDF]
arXiv, 2005 We consider parameter estimation in a regression model corresponding to an iid sequence of censored observations of a finite state modulated renewal process. The model assumes a similar form as in Cox regression except that the baseline intensities are functions of the backwards recurrence time of the process and a time dependent covariate. As a result
arxiv
Haematologica, 2012 Background Myelofibrosis is a myeloproliferative stem cell disorder curable exclusively by allogeneic hematopoietic stem cell transplantation and is associated with substantial mortality and morbidity. The aim of this study was to assess disease-specific
Markus Ditschkowski +6 more
doaj +1 more source
Scientific Reports, 2023 The posttransplant relapse in Ph-positive ALL increases the risk of death. There is an unmet need for instruments to predict the risk of relapse and plan prophylaxis. In this study, we analyzed posttransplant data by machine learning algorithms.
Kseniia S. Afanaseva +6 more
doaj +1 more source
Using machine learning on new feature sets extracted from 3D models of broken animal bones to classify fragments according to break agent [PDF]
arXiv, 2022 Distinguishing agents of bone modification at paleoanthropological sites is at the root of much of the research directed at understanding early hominin exploitation of large animal resources and the effects those subsistence behaviors had on early hominin evolution.
arxiv
VENOOCCLUSIVE DISEASE OF THE LIVER FOLLOWING BONE MARROW TRANSPLANTATION
Transplantation, 1987 Review of 235 consecutive patients undergoing bone marrow transplantation was performed in order to define the clinical syndrome of venoocclusive disease of the liver (VOD) in these patients.
Richard J. Jones +9 more
semanticscholar +1 more source
Journal of Interdisciplinary Medicine, 2017 Acute myeloid leukemia (AML) is a cancerous disease affecting the myeloid line of the bone marrow cells. FLT3, also known as CD135, is a proto-oncogene, which, if mutated, leads to different types of cancer.
Bzduch Árpád +5 more
doaj +1 more source
Deep Reinforcement Learning for Dynamic Treatment Regimes on Medical Registry Data [PDF]
arXiv, 2018 This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real-life complexity in heterogeneous disease ...
arxiv
Towards a New Spatial Representation of Bone Remodeling [PDF]
, 2011 Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis and multiple myeloma. Computational and mathematical modeling can aid in therapy and treatment as well as understanding fundamental biology. Different approaches to modeling give insight into different aspects of a phenomena so it is useful to have an arsenal ...
arxiv +1 more source
Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1 [PDF]
, 2014 Massive research efforts are now underway to develop a cure for HIV infection, allowing patients to discontinue lifelong combination antiretroviral therapy (ART). New latency-reversing agents (LRAs) may be able to purge the persistent reservoir of latent virus in resting memory CD4+ T cells, but the degree of reservoir reduction needed for cure remains
arxiv +1 more source