Results 81 to 90 of about 356,556 (259)

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

open access: yesSignal Transduction and Targeted Therapy
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used in cancer treatment due to
Xiujian Wang   +27 more
doaj   +1 more source

PB2426: SORAFENIB MAINTENANCE TAILORED TO FLT3-MUTATED AML AFTER ALLOGENEIC HCT IS HIGHLY FEASIBLE AND EFFECTIVE: A REAL-LIFE EXPERIENCE

open access: yesHemaSphere, 2023
Elisa Diral   +17 more
doaj   +1 more source

Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies

open access: yesExperimental Hematology & Oncology
Although the efficacy of chimeric antigen receptor (CAR)-T cell therapy has been widely demonstrated, its clinical application is hampered by the complexity and fatality of its side effects.
Linqin Wang   +13 more
doaj   +1 more source

Treatment of pediatric acute lymphoblastic leukemia in India on BFM 95 protocol backbone with relevant modifications and minimal residual disease application - Doable and effective

open access: yesPediatric Hematology Oncology Journal, 2022
Dhwanee Thakkar   +10 more
doaj   +1 more source

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. [PDF]

open access: yes, 1987
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals.
Bordignon, C   +9 more
core  

Therapy of Acute Leukemia by Whole-Body Irradiation and Bone Marrow Transplantation from an Identical Normal Twin

open access: bronze, 1959
John B. Atkinson   +3 more
openalex   +1 more source

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