Results 1 to 10 of about 672,023 (194)

Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva

Orphanet Journal of Rare Diseases, 2022
Background COVID-19, caused by the SARS-CoV-2 virus, is a severe inflammatory condition. Patients with pre-existing conditions including diabetes, hypertension, and cardiovascular disease are at particularly high risk of complications.
Samuel Kou, Sammi Kile, Sai Samhith Kambampati, Evelyn C. Brady, Hayley Wallace, Carlos M. De Sousa, Kin Cheung, Lauren Dickey, Kelly L. Wentworth, Edward C. Hsiao   +9 more
doaj   +1 more source

Bone Quality in CKD Patients: Current Concepts and Future Directions – Part I

Kidney Diseases, 2021
Background: There is ample evidence that patients with CKD have an increased risk of osteoporotic fractures. Bone fragility is not only influenced by low bone volume and mass but also by poor microarchitecture and tissue quality.
Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini   +5 more
doaj   +1 more source

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bone Research, 2022
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape.
Simona Bolamperti, Isabella Villa, Alessandro Rubinacci   +2 more
doaj   +1 more source

Bone Quality in Chronic Kidney Disease Patients: Current Concepts and Future Directions – Part II

Kidney Diseases, 2021
Background: Patients with chronic kidney disease (CKD) have an increased risk of osteoporotic fractures, which is due not only to low bone volume and mass but also poor microarchitecture and tissue quality.
Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini   +5 more
doaj   +1 more source

Transcriptomic characterization of classical monocytes highlights the involvement of immuno-inflammation in bone erosion in Rheumatoid Arthritis

Frontiers in Immunology, 2023
IntroductionEvidence-based data suggest that under inflammatory conditions, classical monocytes are the main source of osteoclasts and might be involved in bone erosion pathophysiology.
Lucas Peixoto Sales, Bidossessi Wilfried Hounkpe, Mariana Ortega Perez, Valéria Falco Caparbo, Diogo Souza Domiciano, Eduardo Ferreira Borba, Georg Schett, Camille Pinto Figueiredo, Rosa Maria Rodrigues Pereira   +8 more
doaj   +1 more source

Low‐Intensity Vibration Protects the Weight‐Bearing Skeleton and Suppresses Fracture Incidence in Boys With Duchenne Muscular Dystrophy: A Prospective, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

JBMR Plus, 2022
The ability of low‐intensity vibration (LIV) to combat skeletal decline in Duchenne Muscular Dystrophy (DMD) was evaluated in a randomized controlled trial.
Maria Luisa Bianchi, Silvia Vai, Giovanni Baranello, Francesca Broggi, Stefan Judex, Thomas Hangartner, Clinton Rubin   +6 more
doaj   +1 more source

Bone erosion in the 2nd metacarpophalangeal head: association with its bone mineral density by HR-pQCT in rheumatoid arthritis patients

BMC Musculoskeletal Disorders, 2021
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease depicted by synovial inflammation leading to local and systemic bone loss. The aim of this study was to evaluate by a HR-pQCT (High Resolution Peripheral Quantitative Computed ...
Camille P. Figueiredo, Mariana O. Perez, Lucas Peixoto Sales, Ana Cristina Medeiros, Valeria F. Caparbo, Rosa M. R. Pereira   +5 more
doaj   +1 more source

Effect of age and gender on serum growth differentiation factor 15 and its relationship to bone density and bone turnover

Bone Reports, 2023
Senescent cells and senescence-associated secretory phenotype (SASP) proteins are involved in age-related bone loss. Growth differentiation factor 15 (GDF 15), a stress-responsive cytokine member of the transforming growth factor-β (TGF-β) superfamily ...
Lorenza Mattia, Fatma Gossiel, Jennifer S. Walsh, Richard Eastell   +3 more
doaj   +1 more source

HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Stem Cell Research & Therapy, 2023
Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden   +4 more
doaj   +1 more source

Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation FacilitiesPlain-Language Summary

Kidney Medicine, 2021
Rationale & Objective: Since January 2017, patients with acute kidney injury requiring dialysis (AKI-D) can be discharged to outpatient dialysis centers for continued hemodialysis (HD) support. We aimed to examine the rate of kidney recovery, time to
Melissa Jordan, Victor Ortiz-Soriano, Aaron Pruitt, Lauren Chism, Lucas J. Liu, Nourhan Chaaban, Madona Elias, B. Peter Sawaya, Jin Chen, Javier A. Neyra   +9 more
doaj   +1 more source