Results 91 to 100 of about 1,181,357 (307)

Late-onset meningeal metastases in liposarcoma: A case report and review of the literature [PDF]

, 2006
Intracranial metastases from liposarcoma are rare and almost always preceded by the development of systemic tumour spread. We report here a case of liposarcoma with spread to the cranial nervous system 23 years after treatment of the primary tumour.
White, J., Cowie, F., Ferguson, M., Stewart, W.   +3 more
core   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Adjusting bone mass for differences in projected bone area and other confounding variables: an allometric perspective. [PDF]

, 2002
The traditional method of assessing bone mineral density (BMD; given by bone mineral content [BMC] divided by projected bone area [Ap], BMD = BMC/Ap) has come under strong criticism by various authors. Their criticism being that the projected bone "area"
Roger L. Holder, Nevill, AM, Holder, Roger, Maffulli, Nicola, Lau, Joseph T. F., Warren T. K. Lee, Lee, WTK, Jack C. Y. Cheng, Nevill, Alan M., Alan M. Nevill, Lee, Warren T. K., Lau, JTF, Joseph T. F. Lau, Maffulli, N, Leung, Sophie S. S. F., Holder, Roger L., Cheng, Jack C. Y., Nicola Maffulli, Cheng, JCY, Leung, SSSF, Sophie S. S. F. Leung   +20 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Diagnostic Strategies and Clinical Practice of Bone Marrow Metastases from Ewing Sarcoma

Zhongliu Fangzhi Yanjiu
Ewing sarcoma (EWS) is an invasive and primary bone tumor with a high incidence in children and adolescents. The presence and extent of metastases at the time of diagnosis remains the most important prognostic factor in determining a patient’s prognosis.
Wanru WANG, Yuhong ZHOU, Qin WANG, Jiaqi XIE, Baorui LIU, Rutian LI   +5 more
doaj   +1 more source

MCA Serum Determination in Breast Carcinoma Patients for the Diagnosis of Bone Metastases

The International Journal of Biological Markers, 1993
Serum MCA levels were determined in 173 consecutive patients with breast cancer in order to assess the clinical utility of MCA for the detection of bone metastases.
L. Dominguez-Ġadea, LM. Martin-Curto, A. Crespo, C. Avila   +3 more
doaj   +1 more source

Prevalence of bone metastases and bone-targeting agent use among solid tumor patients in the United States

, 2015
Rohini K Hernandez,1 Avanti Adhia,2 Sally W Wade,3 Emily O’Connor,1 Jorge Arellano,1 Kevin Francis,2 Hasmik Alvrtsyan,4 Ryan P Million,4 Alexander Liede5 1Amgen Inc., Thousand Oaks, CA, 2Trinity Partners, Waltham, MA, 3Wade Outcomes Research and ...
Arellano J, Million RP, Adhia A, Wade SW, O’Connor E, Francis K, Alvrtsyan H, Hernandez RK, Liede A   +8 more
core  

Hypomagnesemia and vitamin D deficiency complicating bisphosphonate induced hypocalcaemia [PDF]

, 2012
Zolendronic acid is a potent bisphosphonate that is used to treat patients with metastatic cancer by reducing bone pain and preventing skeletal complications of bone metastasis.
Bigeni, Josephine, Vella, Antoine
core  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Bone metastases from urothelial carcinoma. The dark side of the moon

, 2021
Bone metastases are common in genitourinary cancers, but they are underreported and not well researched. Synchronous bone metastases occur in 1.39–5.5% of bladder cancer patients, while 30–40% of cases are metachronous. Bone morphogenetic proteins (BMPs)
Stellato M., Procopio G., Santini D., Cursano M. C., Tonini G., Foderaro S.   +5 more
core   +1 more source