Results 91 to 100 of about 183,117 (350)

Contribution of the immune bone marrow microenvironment to tumor growth and bone deconstruction: implications for improving immunotherapeutic strategies in bone metastasis

Neoplasia: An International Journal for Oncology Research
Bone metastases are frequent complications of many solid tumors, leading to painful skeletal morbidities and increasing mortality for patients with advanced cancer.
E. Massy, C.B. Confavreux, M. Point, E. Bonnelye, P. Clézardin   +4 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Hypomagnesemia and vitamin D deficiency complicating bisphosphonate induced hypocalcaemia [PDF]

, 2012
Zolendronic acid is a potent bisphosphonate that is used to treat patients with metastatic cancer by reducing bone pain and preventing skeletal complications of bone metastasis.
Bigeni, Josephine, Vella, Antoine
core  

Diagnostic Strategies and Clinical Practice of Bone Marrow Metastases from Ewing Sarcoma

Zhongliu Fangzhi Yanjiu
Ewing sarcoma (EWS) is an invasive and primary bone tumor with a high incidence in children and adolescents. The presence and extent of metastases at the time of diagnosis remains the most important prognostic factor in determining a patient’s prognosis.
Wanru WANG, Yuhong ZHOU, Qin WANG, Jiaqi XIE, Baorui LIU, Rutian LI   +5 more
doaj   +1 more source

Targeted Nanomedicine to Treat Bone Metastasis

Pharmaceutics, 2018
Bone metastases are common complications of solid tumors, particularly those of the prostate, breast, and lungs. Bone metastases can lead to painful and devastating skeletal-related events (SREs), such as pathological fractures and nerve compressions ...
Isaac M. Adjei, Madison N. Temples, Shannon B. Brown, Blanka Sharma   +3 more
doaj   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Prevalence of bone metastases and bone-targeting agent use among solid tumor patients in the United States

, 2015
Rohini K Hernandez,1 Avanti Adhia,2 Sally W Wade,3 Emily O’Connor,1 Jorge Arellano,1 Kevin Francis,2 Hasmik Alvrtsyan,4 Ryan P Million,4 Alexander Liede5 1Amgen Inc., Thousand Oaks, CA, 2Trinity Partners, Waltham, MA, 3Wade Outcomes Research and ...
Arellano J, Million RP, Adhia A, Wade SW, O’Connor E, Francis K, Alvrtsyan H, Hernandez RK, Liede A   +8 more
core  

A structural and functional model for human bone sialoprotein

, 2013
Human bone sialoprotein (BSP) is an essential component of the extracellular matrix of bone. It is thought to be the primary nucleator of hydroxyapatite crystallization, and is known to bind to hydroxyapatite, collagen, and cells.
Durrant, Marcus, Vincent, Kevin
core   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Bone Metastases; Basic Aspects

, 2019
International audienceBone metastases, the spread of cancer to the bones, occur frequently in patients with advanced disease and contribute substantially to morbidity and mortality in cancer patients.
Mauro, Paola, Di, Clézardin, Philippe, Reynaud, Caroline, E, Diaz-Latoud, Chantal, Bernard, Margaux   +4 more
core   +1 more source